Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Vision Science, Nankai University Eye Hospital, Clinical College of Ophthalmology, Tianjin Medical University, 4, Gansu Road, Heping District, Tianjin, 300020, People's Republic of China.
BMC Ophthalmol. 2022 Jun 6;22(1):251. doi: 10.1186/s12886-022-02470-3.
To analyze the incidence and severity of retinopathy of prematurity (ROP) in north China, and to evaluate the effectiveness of different ROP screening criteria.
The screening data of premature infants were collected from 2016 to 2021. The severity of ROP was graded according to the International Classification of Retinopathy of Prematurity (2005). And the treatment for ROP followed the Early Treatment for Retinopathy of Prematurity Cooperative Group. The effects of gestational age (GA) and birth weight (BW) on the incidence and severity of ROP were evaluated. The screening data were also analyzed using different ROP screening guidelines.
A total of 4069 infants underwent ROP screening, and 728 infants (17.9%) were diagnosed with ROP. Of those, 78 infants (1.9%) received treatments. Gestational age and BW showed significant differences between infants with and without ROP (29.1 ± 2.1w vs. 32.9 ± 2.6w, p < 0.001; 1362.7 ± 427.3 g vs. 1751.9 ± 509.4 g, p < 0.001; respectively). Fifty-six infants (7.69%), 188 infants (25.82%), and 104 infants (14.29%) in all infants with ROP would have been missed according to the China, USA, and UK screening guidelines respectively. If GA ≤ 33 weeks and/or BW ≤ 2100 g were considered as screening criteria, only one infant (0.14%) with critical systemic illness was missed diagnosed with severe ROP.
Gestational age and BW are major risk factors for the incidence and severity of ROP. And the incidence and treatment rate of ROP in Tianjin is similar to that reported in the other regions of China. Modified ROP screening criteria were considered to be more effective in Tianjin.
分析中国北方早产儿视网膜病变（ROP）的发生率和严重程度，并评估不同 ROP 筛查标准的效果。
收集 2016 年至 2021 年早产儿的筛查数据。ROP 的严重程度根据国际早产儿视网膜病变分类（2005 年）进行分级。ROP 的治疗遵循早产儿视网膜病变早期治疗合作组的标准。评估胎龄（GA）和出生体重（BW）对 ROP 发生率和严重程度的影响。还使用不同的 ROP 筛查指南分析筛查数据。
共有 4069 名婴儿接受了 ROP 筛查，其中 728 名（17.9%）被诊断为 ROP。其中，78 名（1.9%）接受了治疗。ROP 患儿与非 ROP 患儿的 GA 和 BW 差异有统计学意义（29.1±2.1 周 vs. 32.9±2.6 周，p<0.001；1362.7±427.3g vs. 1751.9±509.4g，p<0.001）。按照中国、美国和英国的筛查指南，所有 ROP 患儿中分别有 56 名（7.69%）、188 名（25.82%）和 104 名（14.29%）患儿会被漏诊。如果将 GA≤33 周和/或 BW≤2100g 作为筛查标准，仅有 1 名（0.14%）患有严重全身疾病的患儿会被漏诊为严重 ROP。
GA 和 BW 是 ROP 发生率和严重程度的主要危险因素。天津的 ROP 发生率和治疗率与中国其他地区相似。在天津，改良的 ROP 筛查标准被认为更有效。
