Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu, China.
Department of Health Management Center, West China Hospital, Sichuan University, Chengdu, China.
Front Endocrinol (Lausanne). 2022 May 20;13:787268. doi: 10.3389/fendo.2022.787268. eCollection 2022.
To investigate the association between metabolic syndrome (MetS) and its components and prostate cancer (PCa).
This study enrolled 482 943 consecutive men who underwent routine health checkups at the Health Management Center of West China Hospital Between 2010 and 2017. For patients with elevated prostate-specific antigen (PSA) levels or color Doppler ultrasound indicating abnormal prostates, we recommended prostate puncture and follow-up. We used the chi-square test and independent t-test for categorical variables and continuous variables, respectively. We used logistic regression analysis to evaluate the effects of MetS and its components on prostate cancer risk.
We found that the incidence of PCa in Chinese men over 40 years of age was 0.1%. Among the 85882 participants, 31.5% (27016/85882) of the patients were diagnosed with MetS. PCa was associated with older age, higher PSA levels, lighter weight and shorter height, hypertension, elevated fasting blood glucose (FBG) and HDL cholesterol level, lower triglycerides. After excluded the interference of other factors in multivariate logistic analysis, we found that MetS, hypertension, hyperlipidemia, hyperglycemia, and obesity were not related to the risk of PCa. High age and PSA levels were risk factors for prostate cancer.
High age and PSA levels were risk factors for prostate cancer. MetS, hypertension, hyperlipidemia, hyperglycemia, and obesity were not related to the risk of PCa.
研究代谢综合征（MetS）及其各组分与前列腺癌（PCa）之间的相关性。
本研究纳入了 2010 年至 2017 年在华西医院健康管理中心接受常规健康检查的 482943 例连续男性患者。对于前列腺特异性抗原（PSA）水平升高或彩色多谱勒超声示前列腺异常的患者，我们建议进行前列腺穿刺和随访。我们分别使用卡方检验和独立 t 检验来比较分类变量和连续变量。使用 logistic 回归分析来评估 MetS 及其各组分对前列腺癌风险的影响。
我们发现中国 40 岁以上男性的 PCa 发病率为 0.1%。在 85882 名参与者中，31.5%（27016/85882）的患者被诊断为 MetS。PCa 与年龄较大、较高的 PSA 水平、较轻的体重和较短的身高、高血压、空腹血糖（FBG）和高密度脂蛋白胆固醇水平升高、甘油三酯水平降低有关。在多变量 logistic 分析排除其他因素的干扰后，我们发现 MetS、高血压、高脂血症、高血糖和肥胖与 PCa 风险无关。高龄和 PSA 水平是前列腺癌的危险因素。
高龄和 PSA 水平是前列腺癌的危险因素。MetS、高血压、高脂血症、高血糖和肥胖与 PCa 风险无关。
