Department of Molecular Immunology, Ruhr-University Bochum, Bochum, Germany.
Department of Molecular Immunology and Cell Biology, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.
Front Immunol. 2022 May 20;13:894580. doi: 10.3389/fimmu.2022.894580. eCollection 2022.
γδ T cells are unconventional T cells, distinguished from αβ T cells in a number of functional properties. Being small in number compared to αβ T cells, γδ T cells have surprised us with their pleiotropic roles in various diseases. γδ T cells are ambiguous in nature as they can produce a number of cytokines depending on the (micro) environmental cues and engage different immune response mechanisms, mainly due to their epigenetic plasticity. Depending on the disease condition, γδ T cells contribute to beneficial or detrimental response. In this review, we thus discuss the dichotomous nature of γδ T cells in cancer, neuroimmunology and infectious diseases. We shed light on the importance of equal consideration for systems immunology and personalized approaches, as exemplified by changes in metabolic requirements. While providing the status of immunotherapy, we will assess the metabolic (and other) considerations for better outcome of γδ T cell-based treatments.
γδ T 细胞是非常规 T 细胞，在许多功能特性上与 αβ T 细胞不同。与 αβ T 细胞相比，γδ T 细胞数量较少，但它们在各种疾病中的多效性作用令我们感到惊讶。γδ T 细胞的性质是模糊的，因为它们可以根据（微）环境线索产生多种细胞因子，并通过不同的免疫反应机制发挥作用，主要是由于它们的表观遗传可塑性。根据疾病情况的不同，γδ T 细胞有助于有益或有害的反应。因此，在这篇综述中，我们讨论了 γδ T 细胞在癌症、神经免疫学和传染病中的双重性质。我们强调了系统免疫学和个性化方法同等重要性的重要性，例如代谢需求的变化。在提供免疫疗法现状的同时，我们将评估代谢（和其他）方面的考虑因素，以提高基于 γδ T 细胞的治疗效果。
