Dikov Dorian, Koleva Maria, Simitchiev Kiril, Baltov Marin, Sarafian Victoria
Department of General and Clinical Pathology, Medical Faculty, Medical University of Plovdiv, Plodiv, Bulgaria.
Service d'Anatomie et Cytologie Pathologiques, Grand Hôpital de l'Est Francilien, Jossigny, France.
Histol Histopathol. 2022 Aug;37(8):749-755. doi: 10.14670/HH-18-479. Epub 2022 Jun 7.
Ductal epithelial changes (lympho-epithelial lesions-LEL) in prostatic chronic inflammation (CI) are not well studied so far.
to investigate LEL immediately adjacent to prostatic CI.
We studied LEL in 144 prostatic surgical and autopsy specimens in various types of prostatic CI: NIH-category IV prostatitis (histologic prostatitis-HP), nonspecific granulomatous prostatitis (NSGP), and the reactive lymphoid infiltrates in the vicinity of benign prostatic hyperplasia (BPH) and prostate adenocarcinoma (PCa). CI is scored as low and high grade (LG, HG) according to the severity of inflammation.
LEL was identified in all types of prostatic specimens and in all types of prostatic CI: in 70.9% of patients with HP; in 100% of cases with NSGP; in 68.7% and in 80% adjacent to BPH and PCa respectively. Statistical analysis showed a significant correlation of the presence of LEL with HG CI (p<0.001). LEL showed strong membranous PD-L1 expression.
The study presents the first attempt to examine LEL in inflammatory human prostate. PD-L1 positive LEL have no diagnostic organ specificity, although they are a constant histological finding in HG prostatic CI. LEL, inducible after birth by CI, are an integral part of prostate-associated lymphoid tissue (PALT) and of the inflammatory prostatic microenvironment.
前列腺慢性炎症（CI）中的导管上皮变化（淋巴上皮病变-LEL）目前尚未得到充分研究。
研究紧邻前列腺CI的LEL。
我们在144例前列腺手术和尸检标本中研究了不同类型前列腺CI中的LEL：美国国立卫生研究院（NIH）IV类前列腺炎（组织学前列腺炎-HP）、非特异性肉芽肿性前列腺炎（NSGP），以及良性前列腺增生（BPH）和前列腺腺癌（PCa）附近的反应性淋巴浸润。根据炎症严重程度，CI分为低级别和高级别（LG，HG）。
在所有类型的前列腺标本和所有类型的前列腺CI中均发现了LEL：在70.9%的HP患者中；在100%的NSGP病例中；在分别紧邻BPH和PCa的病例中，LEL的发生率分别为68.7%和80%。统计分析显示LEL的存在与HG CI显著相关（p<0.001）。LEL显示出强烈的膜性PD-L1表达。
本研究首次尝试在人类炎性前列腺中检测LEL。PD-L1阳性的LEL没有诊断器官特异性，尽管它们是HG前列腺CI中持续存在的组织学表现。LEL在出生后可由CI诱导产生，是前列腺相关淋巴组织（PALT）和炎性前列腺微环境的组成部分。
