College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, 712100, P. R. China.
State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, P. R. China.
Small. 2022 Jul;18(27):e2201826. doi: 10.1002/smll.202201826. Epub 2022 Jun 7.
Cephalopods possess a dynamic coloration behavior to change their iridescence due to the concentration-induced optical properties of chromatophores and hierarchical assembly of reflectin. However, cephalopods rarely have iridescence in the darkfield. It would be interesting to develop color-tunable fluorescent hierarchical nanoassemblies with concentration-encoded emission. Herein, to construct the bioavailable fluorophore with dynamic coloration properties, a histidine-rich peptide is designed, which can self-assemble into hierarchical nanoassemblies stabilized by hydrogen bonds and π-π stacking interactions. The peptidyl nanoassemblies emit fluorescent iridescence, encompassing the blue to orange region due to the assembly-induced emission. The fluorescence of histidine-rich peptides is color-tunable and reversible, which can be dynamically controlled in a concentration-encoded mode. Due to the coloration ability of histidine-rich peptides, fluorescent polychromatic human cells are developed, highlighting its potential role as a fluorescent candidate for future applications such as bioimaging, implantable light-emitting diodes, and photochromic camouflage.
头足类动物具有动态的变色行为，可以改变它们的虹彩，这是由于色素的浓度诱导光学特性和反射蛋白的分层组装。然而，头足类动物在暗场中很少有虹彩。有趣的是，开发具有浓度编码发射的可调谐荧光分层纳米组装体。在此，为了构建具有动态变色特性的生物可用荧光团，设计了一种富含组氨酸的肽，它可以通过氢键和π-π堆积相互作用自组装成分层纳米组装体。由于组装诱导的发射，肽基纳米组装体发射出包含蓝色到橙色区域的荧光虹彩。由于组氨酸丰富的肽的显色能力，开发出了荧光多色的人类细胞，突出了其作为未来生物成像、可植入发光二极管和光致变色伪装等应用的荧光候选物的潜在作用。
