Clin Neuropathol. 2022 Jul-Aug;41(4):153-156. doi: 10.5414/NP301493.
The long-awaited 5th edition of the WHO brain tumor classification has put considerable emphasis on the importance of diagnostic DNA methylation profiling. In this article, the authors comparatively discuss selected practical aspects as well as general advantages and limitations of array- versus nanopore sequencing-based approaches to methylome profiling.
期待已久的第 5 版世界卫生组织脑肿瘤分类非常强调诊断性 DNA 甲基化分析的重要性。本文作者比较讨论了基于阵列和纳米孔测序的甲基化组分析方法的一些选定实际方面以及一般优势和局限性。
