Mammadova Ayshan, Eriş Esra, Solmaz Zeynep Sena, Kara Ayşe Taşçı, Atasoy Aydın, Gürsel Gül
Gazi University School of Medicine, Department of Pulmonary Disease, Division of Critical Care Medicine Gazi University.
Gazi University School of Medicine Critical Care Fellowship Program Gazi University Turkey.
Rev Recent Clin Trials. 2022 Jun 6. doi: 10.2174/1574887117666220606114549.
Recent literature suggests that the respiratory rate oxygenation (ROX) index may be a useful parameter in predicting intubation indication in hypoxemic patients.
In this study, we evaluated the accuracy of the ROX index in predicting intubation, length of stay in the ICU, and mortality in ICU patients with hypoxemic respiratory failure with and without hypercapnia.
Single-centre retrospective cohort study of 290 patients, with a preliminary diagnosis of respiratory failure, who were treated with low flow oxygen systems. Demographics, medical history, clinical, laboratory, treatment, and prognostic data were obtained from the electronic records of the hospital. The ROX index was calculated at the time of ICU admission.
Thirty-seven percent of non-hypercapnic and 69% of hypercapnic patients were intubated (p:0.005). In hypercapnic patients, ROX: 6.9 had highest sensitivity (81%) and specificity (65%) values for intubation (p:0.005). In non-hypercapnic patients, ROX: 6.2 had the highest sensitivity (81%) and specificity (40%) values. While 11% of hypercapnic patients and 30% of non-hypercapnic patients were died (p:0.05), 22% of hypercapnic patients and 33% of non-hypercapnic patients stayed in the ICU longer than 14 days (p:0.044). The highest sensitivity and specificity values were found for mortality in hypercapnic patients; for ROX value of 5.94 (sensitivity:86%, specificity:61%) and for ICU stay longer than 14 days; for ROX value of 7.4 (sensitivity:71%, specificity:68%).
Results of our study suggest that ROX index calculated during ICU admission can be helpful in predicting intubation indication and length of ICU stay in patients with respiratory failure and hypercapnia may influence the cutoff values.
近期文献表明，呼吸频率氧合（ROX）指数可能是预测低氧血症患者插管指征的有用参数。
在本研究中，我们评估了ROX指数在预测合并或不合并高碳酸血症的低氧性呼吸衰竭ICU患者的插管情况、ICU住院时间和死亡率方面的准确性。
对290例初步诊断为呼吸衰竭并接受低流量氧疗系统治疗的患者进行单中心回顾性队列研究。从医院电子记录中获取人口统计学、病史、临床、实验室、治疗和预后数据。在ICU入院时计算ROX指数。
37%的非高碳酸血症患者和69%的高碳酸血症患者接受了插管（p：0.005）。在高碳酸血症患者中，ROX：6.9时插管的敏感性（81%）和特异性（65%）最高（p：0.005）。在非高碳酸血症患者中，ROX：6.2时敏感性（81%）和特异性（40%）最高。11%的高碳酸血症患者和30%的非高碳酸血症患者死亡（p：0.05），22%的高碳酸血症患者和33%的非高碳酸血症患者在ICU停留时间超过14天（p：0.044）。高碳酸血症患者死亡率的敏感性和特异性值最高；ROX值为5.94时（敏感性：86%，特异性：61%），ICU停留时间超过14天时；ROX值为7.4时（敏感性：71%，特异性：68%）。
我们的研究结果表明，ICU入院时计算的ROX指数有助于预测呼吸衰竭患者的插管指征，高碳酸血症可能会影响截断值。
