2000-2020 年全球眼科研究成果，特别关注北欧的贡献。
Worldwide ophthalmological research production 2000-2020, with special focus on the Nordic contribution.
机构信息
Department of Biomedical and Clinical Sciences, Linköping University, Linköping.
出版信息
Acta Ophthalmol. 2022 Dec;100(8):e1760-e1766. doi: 10.1111/aos.15200. Epub 2022 Jun 7.
PURPOSE
To explore the trends in worldwide ophthalmic research production over a 21-year period in relation to journals, contributing countries and dominating topics with special focus on the Nordic region.
METHODS
Articles published between 2000 and 2020 in 20 top-ranked ophthalmology journals were included. Number of articles and impact points were measured per country for each year. The most frequently occurring keywords were calculated worldwide and for the top five contributing countries and the Nordic countries. Trends were explored using linear regression.
RESULTS
The analysis included 65 220 articles. Linear regression showed an increase with 56 articles per year (β = 56.3, R = 0.72, p-value < 0.01). The United States published the most articles, comprising 35% of the worldwide total, followed by the United Kingdom (9%) and Japan (7%). Population-adjusted productivity revealed that Iceland was the most prolific country with 10 articles per million inhabitants/year. Singapore was second and Denmark third with corresponding numbers of nine and seven. Analysing regional trends, Asia had the largest increase in yearly number of articles (β = 29.1, R = 0.89, p-value < 0.01). The strongest positive trend was observed in China (β = 15.7, R = 0.94, p-value < 0.01). The Nordic countries contributed with 3.6% of worldwide ophthalmological papers. Among these, Denmark was the only country with a significant positive trend in impact points per million inhabitants per year (β = 0.6, R = 0.54, p-value < 0.01). The most frequently occurring eye disease within the whole time frame was myopia (5.8%) followed by macular degeneration (5.4%) and glaucoma (5.3%). Linear regression showed a significant increase in the proportion of articles about diabetic retinopathy (β = 0.2%, R = 0.88, p-value < 0.01) a significant decrease in the proportion in articles about cataract (β = -0.1%, R = 0.70, p-value < 0.01) and myopia (β = -0.1%, R = 0.67, p-value < 0.01).
CONCLUSIONS
The worldwide ophthalmic research productivity has maintained a growing trend from 2000 to 2020. While North America and Europe are the major contributors, the scientific activity in Asia and especially China is growing impressively. With the current progress, Asia is forecast to outweigh Europe in 2025 and North America in 2033. Diabetic retinopathy was the most common eye disease in ophthalmologic papers in 2020, and also the topic with the strongest positive trend during 2000-2020.
目的
探讨 21 年来全球眼科研究成果在期刊、贡献国家和主导主题方面的趋势，特别关注北欧地区。
方法
纳入了 2000 年至 2020 年间发表在 20 种顶级眼科期刊上的文章。对每年每个国家的文章数量和影响点数进行了测量。计算了全球以及前 5 个贡献国家和北欧国家出现频率最高的关键词。使用线性回归探索趋势。
结果
分析共纳入 65220 篇文章。线性回归显示，每年增加 56 篇（β=56.3，R²=0.72，p 值<0.01）。美国发表的文章最多，占全球总数的 35%，其次是英国（9%）和日本（7%）。人口调整后的生产力显示，冰岛是最具生产力的国家，每百万居民/年发表 10 篇文章。新加坡排名第二，丹麦排名第三，相应数字为 9 和 7。分析区域趋势，亚洲的年度文章数量增长最大（β=29.1，R²=0.89，p 值<0.01）。中国的正趋势最强（β=15.7，R²=0.94，p 值<0.01）。北欧国家贡献了全球眼科论文的 3.6%。其中，丹麦是唯一一个在每年每百万居民的影响点数方面呈显著正趋势的国家（β=0.6，R²=0.54，p 值<0.01）。在整个时间范围内，最常见的眼部疾病是近视（5.8%），其次是黄斑变性（5.4%）和青光眼（5.3%）。线性回归显示，关于糖尿病性视网膜病变的文章比例显著增加（β=0.2%，R²=0.88，p 值<0.01），关于白内障的文章比例显著下降（β=-0.1%，R²=0.70，p 值<0.01）和近视（β=-0.1%，R²=0.67，p 值<0.01）。
结论
2000 年至 2020 年期间，全球眼科研究成果保持增长趋势。北美和欧洲是主要贡献者，但亚洲，尤其是中国的科学活动正在令人印象深刻地增长。按照目前的进展，亚洲预计将在 2025 年超过欧洲，在 2033 年超过北美。2020 年，糖尿病性视网膜病变是眼科文献中最常见的眼部疾病，也是 2000-2020 年期间正趋势最强的主题。
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