三甲双酮氧化能力的年龄相关性变化。
Age-related changes in trimethadione oxidizing capacity.
作者信息
Tanaka E, Ishikawa A, Ono A, Okamura T, Misawa S
出版信息
Br J Clin Pharmacol. 1987 Mar;23(3):355-7. doi: 10.1111/j.1365-2125.1987.tb03058.x.
The metabolism of trimethadione (TMO) following oral administration (4 mg kg-1) has been studied in 11 young male and 11 elderly male patients. The elimination half-life (h) of TMO was 11.8 +/- 1.4 (mean +/- s.e. mean) in the young and 23.5 +/- 2.17 in the elderly (P less than 0.01). Total body clearance (1 h-1 kg-1) was 41.4 +/- 2.8 in the young and 29.0 +/- 2.4 in the elderly (P less than 0.01). The apparent volume of distribution (1 kg-1) was 0.67 +/- 0.03 in the young and 0.65 +/- 0.04 in the elderly. Serum dimethadione (DMO)/TMO ratios at 4 h were 0.65 +/- 0.03 in the young and 0.46 +/- 0.03 in the elderly (P less than 0.01). These results suggest that N-demethylation of TMO is inversely related to age.
对11名年轻男性患者和11名老年男性患者进行了口服三甲基二酮（TMO，4毫克/千克）后的代谢研究。TMO的消除半衰期（小时）在年轻患者中为11.8±1.4（均值±标准误均值），在老年患者中为23.5±2.17（P<0.01）。总体清除率（升/小时/千克）在年轻患者中为41.4±2.8，在老年患者中为29.0±2.4（P<0.01）。表观分布容积（升/千克）在年轻患者中为0.67±0.03，在老年患者中为0.65±0.04。4小时时血清二甲双酮（DMO）/TMO比值在年轻患者中为0.65±0.03，在老年患者中为0.46±0.03（P<0.01）。这些结果表明，TMO的N-去甲基化与年龄呈负相关。
Zotero 插件