Department of Prosthodontics, School of Dentistry and Department of Microbiology, Immunology and Parasitology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Present address: Analysis and Testing Center, Nanchang University, 235 Nanjing East Load, Qingshan Lake District, Nanchang, PR China.
Microbiology (Reading). 2022 Jun;168(6). doi: 10.1099/mic.0.001196.
Lactobacilli have been considered as major contributors to human dental caries for over a century. Recent model studies have shown that when compared to a keystone pathogen of human dental caries, the ability of lactobacilli to form biofilms is poor, although differences exist between the different major species. Further studies using molecular and bioinformatics approaches provide evidence that multiple mechanisms, including adhesin-receptor mediated physical contact with , facilitate the adherence and establishment of lactobacilli on the tooth surface. There is also evidence that under conditions like continuous sugar consumption, weak acids and other antimicrobials such as bacteriocins from lactobacilli can become detrimental to the microbial community, especially those in the proximity. Details on the underlying mechanisms of how different sp. establish and persist in the highly complex microbiota on the tooth surface await further investigation.
乳杆菌被认为是导致人类龋齿的主要因素已有一个多世纪了。最近的模型研究表明，与人类龋齿的关键病原体相比，乳杆菌形成生物膜的能力较差，尽管不同主要物种之间存在差异。进一步使用分子和生物信息学方法的研究提供了证据，多种机制，包括黏附素-受体介导的与牙齿表面的物理接触，促进了乳杆菌的黏附和定植。也有证据表明，在持续摄入糖、弱酸性物质和其他抗菌物质（如来自乳杆菌的细菌素）的情况下，这些物质可能对微生物群落，尤其是邻近的微生物群落造成损害。关于不同种属如何在牙齿表面高度复杂的微生物群中建立和持续存在的潜在机制的详细信息仍有待进一步研究。
