双模纳米探针用于心脏组织成像。

Dual-Mode nanoprobes for heart tissue imaging.

机构信息

Xiamen Key Laboratory of Cardiovascular Disease, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.

NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, No.6 Huanrui North Road, Ruijing Street, Beichen District, Tianjin, 300134, China.

出版信息

Talanta. 2022 Oct 1;248:123641. doi: 10.1016/j.talanta.2022.123641. Epub 2022 Jun 1.

DOI:10.1016/j.talanta.2022.123641

PMID:35671546

Abstract

A new method that simultaneously alters multicolor upconversion luminescence (UCL) and improves overall UCL intensity, predominantly in red-emission bands, is presented here. Remarkedly enhanced temperature sensitivity at ultralow temperatures was also observed in Yb/Cu co-doped NaErF through transition metal Cu-doping. Varying the dopant (Cu) concentration in NaErF:Yb effectively controlled the structure, allowing for blue, green, and red UCL output. Large enhancement across the entire UCL spectrum was observed for Cu-doped upconversion nanoparticles (UCNPs) compared to UCNPs not doped with Cu, resulting from non-radiative energy transfer between Cu and Er. The rapid response of the NaErF:Yb/Cu complex allowed for bioimaging of heart tissue within 1 h. Moreover, the relative sensitivity of UCNPs increased from 0.91% K to 1.48% K with metal Cu doping at an ultralow temperature, which significantly impacts biomarker dependence on UCNPs.

摘要

本文提出了一种新的方法，可同时改变多色上转换发光（UCL）并提高整体 UCL 强度，主要是在红色发射带中。通过过渡金属铜掺杂，在 Yb/Cu 共掺杂的 NaErF 中还观察到了在超低温度下显著增强的温度灵敏度。通过改变 NaErF:Yb 中的掺杂剂（Cu）浓度，有效地控制了结构，从而实现了蓝色、绿色和红色 UCL 输出。与未掺杂 Cu 的 UCNP 相比，Cu 掺杂的上转换纳米粒子（UCNP）在整个 UCL 光谱中表现出了较大的增强，这是由于 Cu 和 Er 之间的非辐射能量转移。NaErF:Yb/Cu 配合物的快速响应允许在 1 小时内对心脏组织进行生物成像。此外，随着金属 Cu 的掺杂，UCNP 的相对灵敏度从 0.91% K 增加到 1.48% K，在超低温度下，这对上转换纳米粒子对生物标志物的依赖性有重大影响。