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在 ST 段抬高型心肌梗死患者中应用普拉格雷碎解片与整片对比的院前治疗-COMPARE CRUSH 试验 1 年随访结果。

Pre-hospital treatment with crushed versus integral tablets of prasugrel in patients presenting with ST-Segment Elevation Myocardial Infarction-1-year follow-up results of the COMPARE CRUSH trial.

机构信息

Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands; Department of Cardiology, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, The Netherlands.

Department of Cardiology, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, The Netherlands.

出版信息

Am Heart J. 2022 Oct;252:26-30. doi: 10.1016/j.ahj.2022.05.022. Epub 2022 Jun 6.

DOI:10.1016/j.ahj.2022.05.022
PMID:35671829
Abstract

The present research letter reports the 1-year clinical outcomes of the randomized COMPARE CRUSH trial, which allocated STEMI patients at first medical contact in the ambulance to receive either crushed or integral tablets of prasugrel loading dose. This trial aimed to investigate whether early enhanced antiplatelet effect constituted by the crushed potent oral P2Y inhibitor prasugrel could lead to improved early myocardial reperfusion and clinical outcomes.

摘要

本研究快报报告了随机 COMPARE CRUSH 试验的 1 年临床结果，该试验将首次医疗接触时的 STEMI 患者随机分配接受负荷剂量的普拉格雷粉碎片剂或完整片剂。该试验旨在研究早期增强的抗血小板效应是否由强效口服 P2Y 抑制剂普拉格雷的粉碎制剂构成，从而改善早期心肌再灌注和临床结局。

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引用本文的文献

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Treatment and Care of Patients with ST-Segment Elevation Myocardial Infarction-What Challenges Remain after Three Decades of Primary Percutaneous Coronary Intervention?ST段抬高型心肌梗死患者的治疗与护理——在直接经皮冠状动脉介入治疗三十年之后仍存在哪些挑战？
J Clin Med. 2024 May 15;13(10):2923. doi: 10.3390/jcm13102923.
2
Prehospital crushed versus integral prasugrel loading dose in STEMI patients with a large myocardial area.院前压碎与大心肌面积 STEMI 患者整体普拉格雷负荷剂量。
EuroIntervention. 2024 Apr 1;20(7):e436-e444. doi: 10.4244/EIJ-D-23-00618.
3
Direct Stenting versus Conventional Stenting in Patients with ST-Segment Elevation Myocardial Infarction-A COMPARE CRUSH Sub-Study.
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J Clin Med. 2023 Oct 20;12(20):6645. doi: 10.3390/jcm12206645.