Laboratoire Barla, 6 rue Barla, 06000, Nice, France.
Institut de Médecine Légale, 11 rue Humann, 67000, Strasbourg, France.
Int J Legal Med. 2022 Sep;136(5):1315-1319. doi: 10.1007/s00414-022-02850-w. Epub 2022 Jun 7.
1-Benzofuran-5-ylpropan-2-amine or 5-APB is a new psychoactive substance (NPS) with empathic effects close to ecstasy (MDMA). Although 5-APB has been observed in fatality cases, the drug has not yet been reported in the context of hidden administration for behaviour impairment, also known as drug-facilitated crime. Such a situation was recently observed on 3 separate occasions in the same dancing club of New Caledonia. It involves 3 women, aged 27, 29, and 33 years who presented, after having drunk a cocktail, anxiety, abnormal movements of the inferior jaw, and aggressiveness. No memory loss was noticed. About 12 h after the event, a urine specimen was collected in the 3 cases. Comprehensive toxicology was requested and only 5-APB was identified, at 6, 8, and 14 ng/mL. Urine ethanol tested negative, which is consistent with the limited intake before the event occurred. These results have demonstrated that NPS are circulating in New Caledonia, which was not previously reported, and that 5-APB, like ecstasy, can be used to modify the behaviour of a subject, as it can be done by a chemical weapon.
1-苯并呋喃-5-基-2-丙胺或 5-APB 是一种新的精神活性物质 (NPS)，具有类似于摇头丸 (MDMA) 的同理心效应。尽管已经在致命病例中观察到 5-APB，但在隐藏的行为障碍管理（也称为药物促进犯罪）背景下，尚未报告该药物。这种情况最近在新喀里多尼亚的同一个舞蹈俱乐部中观察到了 3 次。涉及 3 名年龄分别为 27 岁、29 岁和 33 岁的女性，她们在饮用鸡尾酒后出现焦虑、下颚异常运动和攻击性。未注意到记忆力丧失。事件发生后约 12 小时，在 3 例中收集了尿液样本。要求进行全面的毒理学检查，仅在 6、8 和 14ng/mL 时鉴定出 5-APB。尿液乙醇检测呈阴性，这与事件发生前的有限摄入量一致。这些结果表明，NPS 在新喀里多尼亚流通，这是以前没有报道过的，而 5-APB 与摇头丸一样，可用于改变主体的行为，因为它可以像化学武器一样使用。
