[The effect of hepatoprotectors on lipid metabolism in CCl4-hepatitis].
作者信息
Vengerovskiĭ A I, Chuchalin V S, Paul's O V, Saratikov A S
出版信息
Biull Eksp Biol Med. 1987 Apr;103(4):430-2.
PMID:3567336
Abstract
The hepatoprotective agents, silybinin and essentiale, were shown to prevent the development of lipid metabolism disturbances in the liver and serum of rats with CCl4-hepatitis. Slow accumulation of triglycerides, lysophosphatidylcholine and cardiolipin was observed in animals treated with these drugs, while phosphatidylcholine liver level remained high. Silybinin and essentiale inhibited the production of lipid hydroperoxide, Shiff basis, malonic dialdehyde, intensified the function of tissue antioxidants, activated liver beta-hydroxybutyrate dehydrogenase and depressed the activation of serum phospholipase A.
摘要
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