Department of Oncology, The Second Affiliate Hospital of Xi'an Jiaotong University; Xi'an, Shaanxi, 710004, China.
Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School; Boston, MA 02114, USA.
Theranostics. 2022 May 13;12(9):4147-4162. doi: 10.7150/thno.72803. eCollection 2022.
Enormous efforts have been made to integrate various therapeutic interventions into multifunctional nanoplatforms, resulting in the advance of nanomedicine. Image-guided drug delivery plays a pivotal role in this field by providing specific targeting as well as image navigation for disease prognosis. We demonstrate image-guided surgery and drug delivery for the treatment of lung cancer using nanotheranostic H-dots loaded with gefitinib and genistein. The surgical margin for lung tumors is determined by image guidance for precise tumor resection, while targeted anti-cancer drugs function simultaneously for synergistic combination therapy. Compared to conventional chemotherapies, H-dot complexes could improve the therapeutic efficacy of drugs while reducing the risk of adverse effects and drug resistance owing to their ideal biodistribution profiles, high targetability, low nonspecific tissue uptake, and fast renal excretion. These H-dot complexes have unlocked a unique framework for integrating multiple therapeutic and diagnostic modalities into one nanoplatform.
已经做出了巨大的努力将各种治疗干预整合到多功能纳米平台中，从而推进了纳米医学的发展。图像引导的药物输送在该领域中起着关键作用，它为疾病的预后提供了特定的靶向和图像导航。我们使用载有吉非替尼和染料木黄酮的纳米治疗 H 点来演示用于治疗肺癌的图像引导手术和药物输送。通过图像引导来确定肺肿瘤的手术边界，以进行精确的肿瘤切除，同时靶向抗癌药物同时发挥作用，进行协同联合治疗。与传统化疗相比，由于 H 点复合物具有理想的生物分布、高靶向性、低非特异性组织摄取和快速肾脏排泄等特点，因此可以提高药物的治疗效果，同时降低不良反应和耐药性的风险。这些 H 点复合物为将多种治疗和诊断方式整合到一个纳米平台中开辟了独特的框架。
