Department of Cardiology, Chubu Rosai Hospital, Nagoya, 455-8530, Japan.
Department of Physical Therapy, School of Health Sciences, Nagoya University, Nagoya, 461-8673, Japan.
Future Cardiol. 2022 Aug;18(8):627-634. doi: 10.2217/fca-2021-0135. Epub 2022 Jun 8.
The cardiopulmonary response to exercise in patients with heart failure exhibiting a mildly reduced ejection fraction (41% ≤ EF ≤ 49%) remains unclear. A total of 193 consecutive patients with heart failure (excluding those with coronary artery disease) who underwent cardiopulmonary exercise (CPX) tests were examined. CPX variables were compared among patients with reduced, mildly reduced, and preserved EF. The CPX test responses of patients with mildly reduced EF were similar to those of patients with reduced or preserved EF; however, increases in systolic blood pressure during exercise differed significantly (32 ± 26, 50 ± 24, and 41 ± 31 mmHg, respectively; p = 0.016). Grip strength and an increase in systolic blood pressure during exercise were independently associated with peak oxygen uptake in patients with mildly reduced EF (β = 0.41, 0.35, respectively; p < 0.05). Measurements of grip strength and blood pressure during exercise are useful predictors of prognoses in patients with non-ischemic and mildly reduced EF.
心力衰竭患者射血分数轻度降低（41%≤EF≤49%）时运动的心肺反应尚不清楚。共检查了 193 例连续心力衰竭（不包括冠心病患者）患者心肺运动（CPX）试验。比较了 EF 降低、轻度降低和保留的患者的 CPX 变量。EF 轻度降低患者的 CPX 试验反应与 EF 降低或保留的患者相似；然而，运动期间收缩压的增加有显著差异（分别为 32±26、50±24 和 41±31mmHg；p=0.016）。握力和运动期间收缩压的增加与 EF 轻度降低患者的峰值摄氧量独立相关（β=0.41、0.35；分别为 p<0.05）。运动期间握力和血压的测量是预测非缺血性和 EF 轻度降低患者预后的有用指标。
