在发育早期接触草甘膦除草剂会增加成年小鼠后代的胰岛素敏感性并导致肝脏炎症。
Exposure to glyphosate-based herbicide during early stages of development increases insulin sensitivity and causes liver inflammation in adult mice offspring.
机构信息
Universidade Estadual do Oeste do Paraná, Cascavel, PR, Brazil.
Centro Universitário Fundação Assis Gurgacz, Cascavel, PR, Brazil.
出版信息
Einstein (Sao Paulo). 2022 Jun 6;20:eAO6778. doi: 10.31744/einstein_journal/2022AO6778. eCollection 2022.
OBJECTIVE
To investigate the effect of pre and postnatal exposure to a glyphosate-based herbicide on glucose metabolism and liver histology in adult F1 mice offspring.
METHODS
Female mice (C57Bl/6) received 0.5% of glyphosate (Roundup Original DI®) in drinking water or purified water (Glyphosate Group and Control Group respectively) during pregnancy and lactation. Offspring (F1) were submitted to glucose and insulin tolerance tests and euthanized on postnatal day 150. Body and plasma parameters, and liver histology were analyzed.
RESULTS
Exposure to glyphosate reduced maternal body weight gain during pregnancy and lactation, with no impacts on litter size. Pre and postnatal exposure to glyphosate did not affect body parameters but increased glucose tolerance on postnatal day 60. In spite of glucose tolerance normalization by postnatal day 143, this effect was associated with higher insulin sensitivity relative to mice in the Control-F1 Group. Mice in the Glyphosate-F1 Group had mild and moderate lobular inflammation in the liver.
CONCLUSION
Maternal exposure to glyphosate affected insulin sensitivity and caused hepatic inflammation in adult F1 mice offspring.
目的
研究母体妊娠和哺乳期暴露于草甘膦基除草剂对成年 F1 代小鼠后代葡萄糖代谢和肝脏组织学的影响。
方法
雌性小鼠（C57Bl/6）在妊娠和哺乳期分别给予 0.5%的草甘膦（Roundup Original DI®）饮用水或纯净水（草甘膦组和对照组）。对后代（F1）进行葡萄糖和胰岛素耐量试验，并于出生后 150 天处死。分析体质量和血浆参数以及肝脏组织学。
结果
暴露于草甘膦会降低母体妊娠和哺乳期的体重增加，但对产仔数没有影响。母体妊娠和哺乳期暴露于草甘膦并不影响体质量参数，但会增加出生后 60 天的葡萄糖耐量。尽管到第 143 天葡萄糖耐量恢复正常，但与对照组相比，这种效应与胰岛素敏感性的提高有关。草甘膦 F1 组的小鼠肝脏出现轻度和中度小叶炎症。
结论
母体暴露于草甘膦会影响成年 F1 代小鼠后代的胰岛素敏感性，并导致肝脏炎症。
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