Department of Family Medicine, Korea University Ansan Hospital, College of Medicine, Korea University, Republic of Korea.
Department of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea.
Menopause. 2022 Jun 1;29(6):734-740. doi: 10.1097/GME.0000000000001958.
Existing studies show that women are more susceptible to chronic obstructive pulmonary disease (COPD) and asthma, and that obesity affects the risk of these airway obstructive diseases. We aimed to determine the effect of body mass index (BMI) and waist circumference (WC) on COPD and asthma development in premenopausal and postmenopausal women.
This nationwide population-based cohort study included 1,644,635 women ages ≥30 years without diagnosis of COPD or asthma, who underwent national cancer screening in 2009. We classified them as premenopausal and postmenopausal women based on their menopause status at the time of cancer screening. Baseline BMI and WC were measured, and they were classified into five BMI groups (<18.5 kg/m2, 18.5-23 kg/m2, 23-25 kg/m2, 25-30 kg/m2, and ≥30 kg/m2) and WC groups (<60 cm, 65-75 cm, 75-85 cm, 85-95 cm, and ≥95 cm). The hazard ratios (HRs) for COPD and asthma were measured for each group.
Regardless of the menopausal status, the high BMI and WC groups had a significantly higher COPD and asthma incidence than that of the normal group, and the HRs increased further with increases in BMI and WC. However, the HR in the underweight group was significantly higher among the postmenopausal women. The HR for asthma in the obese group was significantly higher for both premenopausal and postmenopausal women. The HR for COPD was significantly higher in the group with a WC of ≥95 cm for both premenopausal and postmenopausal women, respectively; the HR for asthma was also significantly higher in this group.
Obesity and abdominal obesity are risk factors for COPD and asthma in premenopausal and postmenopausal Korean women. Controlling weight and maintaining a healthy body shape can help prevent COPD and asthma in women.
现有研究表明，女性更容易患慢性阻塞性肺疾病（COPD）和哮喘，而肥胖会影响这些气道阻塞性疾病的风险。我们旨在确定体重指数（BMI）和腰围（WC）对绝经前和绝经后女性 COPD 和哮喘发展的影响。
这是一项全国性基于人群的队列研究，纳入了 1644635 名年龄≥30 岁、无 COPD 或哮喘诊断的女性，她们于 2009 年接受了国家癌症筛查。根据癌症筛查时的绝经状态，我们将她们分为绝经前和绝经后女性。测量了基线 BMI 和 WC，并将其分为 5 个 BMI 组（<18.5kg/m2、18.5-23kg/m2、23-25kg/m2、25-30kg/m2 和≥30kg/m2）和 WC 组（<60cm、65-75cm、75-85cm、85-95cm 和≥95cm）。测量了每个组的 COPD 和哮喘的风险比（HR）。
无论绝经状态如何，高 BMI 和 WC 组的 COPD 和哮喘发病率明显高于正常组，并且随着 BMI 和 WC 的增加，HR 进一步增加。然而，在绝经后女性中，体重过轻组的 HR 明显更高。肥胖组的哮喘 HR 对绝经前和绝经后女性均明显更高。绝经前和绝经后女性的 WC≥95cm 组的 COPD HR 明显更高，该组的哮喘 HR 也明显更高。
肥胖和腹部肥胖是绝经前和绝经后韩国女性 COPD 和哮喘的危险因素。控制体重和保持健康的体型有助于预防女性 COPD 和哮喘。
