Department of Family Medicine, Gachon University Dong Incheon Gil Hospital, Incheon, South Korea.
Department of Family Medicine, Gachon University Gil Medical Center, Incheon, South Korea.
Int J Cancer. 2018 Apr 15;142(8):1554-1559. doi: 10.1002/ijc.31180. Epub 2017 Dec 11.
Although postmenopausal breast cancer (BC) risk has been linked to adiposity, associations between adiposity and premenopausal BC remain unclear. To address this question, we investigated the association of BC risk with measures of adiposity, including body mass index (BMI) and waist circumference (WC), in a large cohort of Asian women. We used a nationwide cohort of adult Korean women selected from the National Health Insurance Corporation database merged with national health examination data from 2009 to 2015. A total of 11,227,948 women were tracked to retrospectively identify incident cases of BC. Our analysis used Cox proportional hazards models to calculate hazard ratios and assess the association of BC risk with BMI and/or WC in both pre- and postmenopausal women. BMI and WC were robustly associated with increased risk for postmenopausal BC (p <0.001 for both BMI and WC) but not with premenopausal BC. Association between WC and premenopausal BC was only statistically significant when considering BMI (p =0.044). In contrast, postmenopausal BC was negatively associated with WC when considering BMI (p =0.011). In premenopausal women, WC may predict increased BC risk when considering BMI. However, in postmenopausal women, WC is not superior to BMI as an indicator of BC risk.
尽管绝经后乳腺癌（BC）风险与肥胖有关，但肥胖与绝经前 BC 之间的关联仍不清楚。为了解决这个问题，我们研究了肥胖指标（包括体重指数（BMI）和腰围（WC））与亚洲女性大型队列中 BC 风险之间的关联。我们使用了从 2009 年至 2015 年全国健康保险协会数据库与国家健康检查数据合并的韩国成年女性全国队列进行研究。共跟踪了 11227948 名女性，以回顾性确定 BC 的发病情况。我们的分析使用 Cox 比例风险模型来计算风险比，并评估 BMI 和/或 WC 与绝经前和绝经后妇女的 BC 风险之间的关联。BMI 和 WC 与绝经后 BC 的风险增加密切相关（BMI 和 WC 均为 p<0.001），但与绝经前 BC 无关。当考虑 BMI 时，WC 与绝经前 BC 之间的关联仅具有统计学意义（p=0.044）。相比之下，当考虑 BMI 时，绝经后 BC 与 WC 呈负相关（p=0.011）。在绝经前妇女中，当考虑 BMI 时，WC 可能预示着 BC 风险增加。然而，在绝经后妇女中，WC 不如 BMI 作为 BC 风险的指标优越。
