J Drugs Dermatol. 2022 Jun 1;21(6):671-673. doi: 10.36849/JDD.6810.
Lichen planopilaris (LPP) is a cicatricial alopecia that presents with patchy or diffuse hair loss at the vertex or parietal scalp. The literature has limited evidence on treatments for this challenging disease, with most reports involving small groups of patients with varied or suboptimal clinical responses. Amongst individuals who do respond to therapy and eventually achieve disease remission, hair regrowth within scarred alopecic patches is rare.1 Herein, we report a patient with biopsy confirmed LPP who demonstrated remarkable hair regrowth at a previously scarred alopecic patch after initiating low-dose naltrexone (LDN) and platelet-rich plasma (PRP), despite minimal response to 4 months of prior therapy with intralesional corticosteroids, topical clobetasol, topical minoxidil, finasteride, doxycycline, and ketoconazole shampoo. This case highlights the importance of remaining flexible and diligent in therapeutic approaches to LPP and the need for more robust literature on prognosis and treatment options for LPP patients. J Drugs Dermatol. 2022;21(6):671-673. doi:10.36849/JDD.6810.
瘢痕性类扁平苔藓（LPP）是一种瘢痕性脱发，表现为头顶或顶枕部斑片状或弥漫性脱发。文献中关于这种具有挑战性疾病的治疗方法的证据有限，大多数报道涉及小群患者，其临床反应各不相同或不理想。在对治疗有反应并最终实现疾病缓解的患者中，在瘢痕性脱发斑块内再生头发的情况很少见。1 在此，我们报告了一位活检证实为 LPP 的患者，在开始低剂量纳曲酮（LDN）和富血小板血浆（PRP）治疗后，先前的瘢痕性脱发斑块上出现了显著的毛发生长，尽管在接受 4 个月的皮损内皮质类固醇、局部卤米松、局部米诺地尔、非那雄胺、多西环素和酮康唑洗发水治疗后反应甚微。该病例强调了在治疗 LPP 时保持治疗方法灵活和勤奋的重要性，以及需要更多关于 LPP 患者预后和治疗选择的强有力文献。J 皮肤病药物杂志。2022;21(6):671-673. doi:10.36849/JDD.6810.
