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Disseminated stroke-like episodes lesions in MELAS are partially reversible with lactate disappearance.

作者信息

Kobayashi Yuya, Karasawa Seishu, Ohashi Nobuhiko, Yamamoto Kanji

机构信息

Department of Neurology, Nagano Municipal Hospital, 1333-1, Tomitake, Nagano, 381-8551, Japan.

出版信息

Acta Neurol Belg. 2023 Aug;123(4):1549-1552. doi: 10.1007/s13760-022-01999-w. Epub 2022 Jun 8.

DOI:10.1007/s13760-022-01999-w
PMID:35674909
Abstract
摘要

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Disseminated stroke-like episodes lesions in MELAS are partially reversible with lactate disappearance.线粒体脑肌病伴乳酸血症和卒中样发作(MELAS)中的播散性卒中样发作性病变部分可随乳酸消失而逆转。
Acta Neurol Belg. 2023 Aug;123(4):1549-1552. doi: 10.1007/s13760-022-01999-w. Epub 2022 Jun 8.
2
Cerebellar stroke-like lesions combined with symmetrical multiple intracranial calcifications in MELAS.线粒体脑肌病伴乳酸血症和卒中样发作(MELAS)中的小脑卒中样病变合并对称性多发颅内钙化
Acta Neurol Belg. 2023 Oct;123(5):1965-1968. doi: 10.1007/s13760-022-02000-4. Epub 2022 Jun 25.
3
[Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episodes(MELAS)].线粒体肌病、脑病、乳酸酸中毒和卒中样发作(MELAS)
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Stroke-like episode involving a cerebral artery in a patient with MELAS.线粒体脑肌病伴乳酸血症和卒中样发作(MELAS)患者出现累及脑动脉的卒中样发作。
Pediatr Neurol. 2005 Jul;33(1):70-1. doi: 10.1016/j.pediatrneurol.2005.01.013. Epub 2005 Apr 13.
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Cerebral arterial and venous MRI abnormalities in MELAS.线粒体脑肌病伴乳酸血症和卒中样发作(MELAS)中的脑动脉和静脉MRI异常
Acta Neurol Belg. 2020 Apr;120(2):455-456. doi: 10.1007/s13760-017-0867-7. Epub 2017 Nov 30.
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Acute Cortical Lesions in MELAS Syndrome: Anatomic Distribution, Symmetry, and Evolution.MELAS 综合征中的急性皮质病变:解剖分布、对称性和演变。
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Findings of 123I-iomazenil SPECT during and after stroke-like episodes in a patient with MELAS.患者出现类似于中风的发作期间和之后的 123I-碘美苯噻唑 SPECT 检查结果。
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Comparison of magnetic resonance spectroscopy (MRS) with arterial spin labeling (ASL) in the differentiation between mitochondrial encephalomyopathy, lactic Acidosis, plus stroke-like episodes (MELAS) and acute ischemic stroke (AIS).磁共振波谱(MRS)与动脉自旋标记(ASL)在鉴别线粒体脑肌病伴乳酸酸中毒及卒中样发作(MELAS)和急性缺血性卒中(AIS)中的比较。
J Clin Neurosci. 2018 Sep;55:65-70. doi: 10.1016/j.jocn.2018.06.015. Epub 2018 Jun 18.
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Neuroimaging of stroke-like episodes in MELAS.线粒体脑肌病伴乳酸血症和卒中样发作(MELAS)中卒中样发作的神经影像学表现
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本文引用的文献

1
Mitochondrial DNA A3243G variant-associated retinopathy: Current perspectives and clinical implications.线粒体 DNA A3243G 变异相关的视网膜病变:当前的观点和临床意义。
Surv Ophthalmol. 2021 Sep-Oct;66(5):838-855. doi: 10.1016/j.survophthal.2021.02.008. Epub 2021 Feb 18.
2
Mitochondrial metabolic stroke: Phenotype and genetics of stroke-like episodes.线粒体代谢性卒中:卒中样发作的表型和遗传学。
J Neurol Sci. 2019 May 15;400:135-141. doi: 10.1016/j.jns.2019.03.021. Epub 2019 Mar 23.
3
A cluster of disseminated small cortical lesions in MELAS: its distinctive clinical and neuroimaging features.
MELAS 中散发的小皮质病变簇:其独特的临床和神经影像学特征。
J Neurol. 2019 Jun;266(6):1459-1472. doi: 10.1007/s00415-019-09283-3. Epub 2019 Mar 19.
4
Acute mitochondrial encephalopathy reflects neuronal energy failure irrespective of which genome the genetic defect affects.急性线粒体脑肌病反映了神经元的能量衰竭,而与遗传缺陷影响哪个基因组无关。
Brain. 2012 Dec;135(Pt 12):3627-34. doi: 10.1093/brain/aws223. Epub 2012 Oct 12.
5
Microangiopathy in the cerebellum of patients with mitochondrial DNA disease.小脑线粒体 DNA 病患者的微血管病。
Brain. 2012 Jun;135(Pt 6):1736-50. doi: 10.1093/brain/aws110. Epub 2012 May 9.
6
Localized cerebral energy failure in DNA polymerase gamma-associated encephalopathy syndromes.DNA 聚合酶γ相关脑病综合征中的局部脑能量衰竭。
Brain. 2010 May;133(Pt 5):1428-37. doi: 10.1093/brain/awq067. Epub 2010 Apr 16.
7
Slowly progressive spread of the stroke-like lesions in MELAS.线粒体脑肌病伴乳酸血症和卒中样发作(MELAS)中卒中样病变的缓慢进行性扩散。
Neurology. 2003 Nov 11;61(9):1238-44. doi: 10.1212/01.wnl.0000091888.26232.fe.