Goldman M, Ambrose N S, Drolc Z, Hawker R J, McCollum C
Br J Surg. 1987 Mar;74(3):184-6. doi: 10.1002/bjs.1800740309.
The extensive morbidity and mortality of intra-abdominal abscess is mainly due to the delay in a diagnosis. The diagnostic accuracy of 111In-labelled mixed leucocytes with gamma imaging has been investigated in 100 consecutive patients including 34 following surgery and 36 with inflammatory bowel disease. White cell scans were performed 24 h following injection of autologous 111In-labelled leucocytes and were compared with clinical outcome where abscess was only diagnosed when pus either discharged or was drained at operation. Gamma images detected 28 of the 30 abscesses with no false positives giving 93 per cent sensitivity and 100 per cent specificity. Loculi of pus were identified in 11 of the 36 patients with inflammatory bowel disease with no errors in interpretation. Inflammation was reported in 15 of the remaining 25 patients with known but not necessarily active inflammatory bowel disease. 111In-labelled leucocyte imaging provides a rapid, safe and precise method for detecting intra-abdominal abscess even in the presence of inflammatory bowel disease.
腹腔内脓肿导致的广泛发病和死亡主要归因于诊断延误。对100例连续患者进行了研究，以探讨铟-111标记的混合白细胞γ显像的诊断准确性，其中包括34例术后患者和36例炎性肠病患者。在注射自体铟-111标记的白细胞后24小时进行白细胞扫描，并与临床结果进行比较，临床结果是只有在手术中脓液排出或引流时才诊断为脓肿。γ显像检测出30个脓肿中的28个，无假阳性结果，敏感性为93%，特异性为100%。36例炎性肠病患者中有11例发现了脓腔，解读无误差。其余25例已知患有炎性肠病但不一定处于活动期的患者中有15例报告有炎症。铟-111标记的白细胞显像为检测腹腔内脓肿提供了一种快速、安全且精确的方法，即使在存在炎性肠病的情况下也是如此。
