Plant G T, Hess R F
Brain. 1987 Apr;110 ( Pt 2):489-515. doi: 10.1093/brain/110.2.489.
Contrast sensitivity was measured at nine locations within the central 10 degrees of the visual field in cases of recovered optic neuritis having varying degrees of residual deficit. A sample of 82 patches of visual field was obtained in 14 cases. Circular patches of vertically orientated sinusoidal gratings, 2.5 degrees in diameter, were used. The gratings were modulated in time at 8 Hz and the effect of spatial frequency on the threshold loss determined at each visual field location. As anticipated from what is known of visual field changes in the disorder there was considerable variation in the magnitude of the contrast threshold elevation at different locations in the visual field in any one case. The variability was more marked in cases with greater overall deficit. Three types of spatial loss were encountered. The most common was a loss which increased at higher spatial frequencies, found in 65 of the 82 patches of visual field examined. In 11 the loss was unaffected by spatial frequency and in the remaining 6 the loss was maximal at an intermediate spatial frequency. There was no instance of a loss maximal at low spatial frequencies. Overall the results indicate that sensitivity to higher spatial frequencies is more likely to be impaired following an attack of optic neuritis. In the combined results the effect of spatial frequency on the threshold elevation was statistically significant at all eccentricities (P less than 0.001). Analysis of the combined results revealed no difference in the mean contrast sensitivity loss at eccentricities of zero, 3.75 degrees or 7.5 degrees for intermediate and low spatial frequencies. There is no evidence from these results to suggest that the central foveal projection (papillomacular bundle) is more likely to be affected following an attack of optic neuritis than the projections of other eccentricities within the central 10 degrees as far as mechanisms subserving luminance vision are concerned at these spatial frequencies. Overall there was slightly greater reduction in acuity within the central 5 degrees than at 7.5 degrees eccentricity (P less than 0.05). This may be accounted for by the finding that higher spatial frequencies are more affected, rather than being related to eccentricity per se.
在不同程度残留缺陷的视神经炎恢复病例中，在视野中央10度范围内的9个位置测量对比敏感度。14例患者共获取了82个视野斑块样本。使用直径为2.5度的垂直方向正弦光栅的圆形斑块。光栅以8赫兹的频率进行时间调制，并确定空间频率对每个视野位置阈值损失的影响。正如从该疾病已知的视野变化所预期的那样，在任何一个病例中，视野不同位置的对比阈值升高幅度存在相当大的差异。在总体缺陷较大的病例中，变异性更为明显。遇到了三种类型的空间损失。最常见的是在较高空间频率时增加的损失，在所检查的82个视野斑块中有65个出现这种情况。在11个斑块中，损失不受空间频率影响，在其余6个斑块中，损失在中间空间频率时最大。没有在低空间频率时损失最大的情况。总体而言，结果表明视神经炎发作后，对较高空间频率的敏感度更有可能受损。综合结果中，空间频率对阈值升高的影响在所有偏心度下均具有统计学意义（P小于0.001）。对综合结果的分析显示，对于中间和低空间频率，在偏心度为零、3.75度或7.5度时，平均对比敏感度损失没有差异。就这些空间频率下服务于亮度视觉的机制而言，这些结果没有证据表明视神经炎发作后，中央凹投影（乳头黄斑束）比中央10度内其他偏心度的投影更容易受到影响。总体而言，中央5度范围内视力的降低略大于偏心度为7.5度时（P小于0.05）。这可能是由于发现较高空间频率受到的影响更大，而不是与偏心度本身有关。
