Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M Health, Texas A&M University, Houston, Texas.
Department of Translational Medical Sciences, College of Medicine, Texas A&M University, Houston, Texas.
Cancer Immunol Res. 2022 Jul 1;10(7):786. doi: 10.1158/2326-6066.CIR-22-0403.
The immune receptor repertoire is a set of cellular receptors responsible for recognizing foreign antigens. Characterizing the immune receptor repertoire is critical to understanding mechanisms of human adaptive immunity and developing new approaches to cancer immunotherapy. In this issue, Song and colleagues utilize an advanced bioinformatics pipeline on large-scale samples to investigate the diversity of receptor repertoires in tumors and identify factors correlated with favorable outcomes. The result highlights the role of B cells in immunotherapy responses and suggests establishing B cells as biomarkers in future research. See related article by Song et al., p. 788 (3).
免疫受体库是一组负责识别外来抗原的细胞受体。对免疫受体库进行特征分析对于理解人类适应性免疫机制和开发癌症免疫治疗新方法至关重要。在本期杂志中，Song 及其同事利用一种先进的生物信息学管道在大规模样本上进行研究，以调查肿瘤中受体库的多样性，并确定与良好结果相关的因素。这一结果强调了 B 细胞在免疫治疗反应中的作用，并表明将 B 细胞确立为未来研究中的生物标志物。请参阅 Song 等人的相关文章，第 788 页（3）。
