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Concurrent Germline / and Mismatch Repair Mutations in Young-Onset Pancreatic and Colorectal Cancer: The Importance of Comprehensive Germline and Somatic Characterization to Inform Therapeutic Options.

作者信息

Ozer Muhammet, Ranganathan Megha, Lecomte Nicolas, Schvartzman Juan M, Walch Henry S, Chatila Walid K, Hong Jungeui, Carlo Maria I, Walsh Michael F, Sheehan Margaret, Mandelker Diana, Ceyhan-Birsoy Ozge, Maio Anna, Kemel Yelena, Iacobuzio-Donahue Christine A, O'Reilly Eileen M, Yu Kenneth H

机构信息

Capital Health Regional Medical Center, Trenton, NJ.

Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY.

出版信息

JCO Precis Oncol. 2022 Jun;6:e2100560. doi: 10.1200/PO.21.00560.

DOI:10.1200/PO.21.00560
PMID:35675575
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9200400/
Abstract
摘要

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本文引用的文献

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Pancreatic Cancer: A Review.胰腺癌：综述。
JAMA. 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027.
2
Risk of Pancreatic Cancer Among Individuals With Pathogenic Variants in the ATM Gene.ATM 基因致病性变异个体的胰腺癌风险。
JAMA Oncol. 2021 Nov 1;7(11):1664-1668. doi: 10.1001/jamaoncol.2021.3701.
3
Pancreas cancer and BRCA: A critical subset of patients with improving therapeutic outcomes.胰腺癌与 BRCA：具有改善治疗效果的关键亚组患者。
Cancer. 2021 Dec 1;127(23):4393-4402. doi: 10.1002/cncr.33812. Epub 2021 Aug 5.
4
Pancreatic Adenocarcinoma, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.胰腺导管腺癌临床实践指南（第 2.2021 版），NCCN 肿瘤学临床实践指南。
J Natl Compr Canc Netw. 2021 Apr 1;19(4):439-457. doi: 10.6004/jnccn.2021.0017.
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The mutational constraint spectrum quantified from variation in 141,456 humans.从 141456 名人类个体的变异中量化的突变约束谱。
Nature. 2020 May;581(7809):434-443. doi: 10.1038/s41586-020-2308-7. Epub 2020 May 27.
6
A practical framework and online tool for mutational signature analyses show inter-tissue variation and driver dependencies.一个用于突变特征分析的实用框架和在线工具显示了组织间的变异和驱动依赖性。
Nat Cancer. 2020 Feb;1(2):249-263. doi: 10.1038/s43018-020-0027-5. Epub 2020 Feb 17.
7
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JAMA Oncol. 2020 May 1;6(5):764-771. doi: 10.1001/jamaoncol.2019.5963.
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