碳酸氢钠封管可能是小儿肠衰竭的一种安全有效的替代方法：一项试点研究。
Sodium Bicarbonate Locks May Be a Safe and Effective Alternative in Pediatric Intestinal Failure: A Pilot Study.
作者信息
Josyabhatla Rohit, Naik Mamta, Liu Yuying, Speer Allison L, Imseis Essam M
机构信息
From the Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX.
the Short Bowel Syndrome Therapy And Rehabilitation (STAR) Team, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX.
出版信息
J Pediatr Gastroenterol Nutr. 2022 Sep 1;75(3):304-307. doi: 10.1097/MPG.0000000000003506. Epub 2022 Jun 7.
This was a retrospective study that compared outcomes in pediatric intestinal failure (IF) patients that were switched from ethanol lock therapy (ELT) to sodium bicarbonate lock therapy (SBLT). The primary outcome was rate of catheter-related blood stream infections (CRBSI). The secondary outcomes were number of hospitalizations, emergency room (ER) visits, central venous catheter (CVC)-related complications. In 4 patients, median rates of CRBSI were 2.77 (interquartile range [IQR] 0.6-5.6) on ELT versus 0 on SBLT per 1000 catheter days ( P = 0.17). The median rates of hospitalizations and ER visits for CVC-related complications were 6.1 (IQR 3.2-10.2) on ELT versus 0 on SBLT (IQR 0-0; P = 0.11) and 2.8 (IQR 2-3.6) on ELT versus 1.8 (IQR 0-3.7) on SBLT per 1000 catheter days ( P = 0.50), respectively. Rates of CVC-related complications were similar. No adverse events were reported. SBLT may be safe and effective for pediatric IF.
这是一项回顾性研究，比较了从乙醇封管疗法（ELT）转换为碳酸氢钠封管疗法（SBLT）的小儿肠衰竭（IF）患者的治疗结果。主要结局是导管相关血流感染（CRBSI）的发生率。次要结局是住院次数、急诊室（ER）就诊次数、中心静脉导管（CVC）相关并发症。4例患者中，ELT组每1000导管日的CRBSI发生率中位数为2.77（四分位间距[IQR]0.6 - 5.6），而SBLT组为0（P = 0.17）。ELT组CVC相关并发症的住院和ER就诊发生率中位数分别为6.1（IQR 3.2 - 10.2），而SBLT组为0（IQR 0 - 0；P = 0.11），以及ELT组每1000导管日为2.8（IQR 2 - 3.6），SBLT组为1.8（IQR 0 - 3.7）（P = 0.50）。CVC相关并发症的发生率相似。未报告不良事件。SBLT可能对小儿IF安全有效。
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