Cholinergic manipulations in the rat basolateral amygdaloid nucleus on locomotor activity induced by amphetamine.

Microinjections of cholinergic antagonists in the vicinity of the basolateral amygdaloid nucleus produced a marked reduction of amphetamine-induced hyperactivity when amphetamine was administered i.p. in relatively large doses (1.5 mg/kg). Cholinergic agonists enhanced locomotor activity induced by relatively small doses of amphetamine (0.5 mg/kg). These observations suggest that cholinergic activity in the amygdala modulates the locomotor response to amphetamine.