Willoughby J O, Menadue M F, Liebelt H
Brain Res. 1987 Feb 24;404(1-2):319-22. doi: 10.1016/0006-8993(87)91386-2.
In conscious rats, serotonin microinjected into the basal hypothalamus caused secretion of GH maximal within 10-25 min. The effects of serotonin on GH were blocked by the non-selective serotonin receptor blocker, metergoline 2.5 mg/kg, but not by the serotonin type 2 receptor blocker, ketanserine 0.2 mg/kg. Injections of serotonin in the preoptic/anterior hypothalamic area were without effect. It is concluded that activation of serotonin receptors, probably type I, on or near GH releasing factor neurons in the arcuate nucleus causes secretion of GH and that serotonin has no direct effect on or near somatostatin neurons in the preoptic anterior hypothalamic area.
在清醒大鼠中，向基底下丘脑微量注射血清素会在10至25分钟内引起生长激素分泌达到最大值。血清素对生长激素的作用可被非选择性血清素受体阻滞剂美替拉酮（2.5毫克/千克）阻断，但不能被血清素2型受体阻滞剂酮色林（0.2毫克/千克）阻断。在视前区/下丘脑前部注射血清素没有效果。得出的结论是，弓状核中生长激素释放因子神经元上或其附近的血清素受体（可能是I型）的激活会导致生长激素的分泌，并且血清素对视前区下丘脑前部的生长抑素神经元没有直接作用。
