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阴道扩张可诱发泌乳大鼠体内与催产素神经元泌乳喷射相关的爆发,并与哺乳刺激相互作用。

Vaginal distension induces milk ejection-related burst of oxytocin neurones interacting with suckling stimuli in lactating rats.

作者信息

Negoro H, Uchide K, Tadokoro Y, Honda K, Higuchi T

出版信息

Brain Res. 1987 Feb 24;404(1-2):371-4. doi: 10.1016/0006-8993(87)91397-7.

DOI:10.1016/0006-8993(87)91397-7
PMID:3567580
Abstract

Milk ejection-related bursts of action potentials recurred at fairly regular intervals during suckling in oxytocin cells of anesthetized lactating rats. Additional milk ejection-related bursts were frequently induced in response to vaginal distension. The latency for the induced response was 2.9 +/- 0.2 s and the size of the induced bursts was similar to that of spontaneous ones. When animals were not suckled, the burst was in no case induced by the stimulus. The findings indicate that the two afferent stimuli arising from the mammary gland and vagina can interact with each other in generating milk ejection-related bursts of oxytocin cells.

摘要

在麻醉的泌乳大鼠的催产素细胞中,与排乳相关的动作电位爆发在哺乳期间以相当规律的间隔反复出现。对阴道扩张的反应经常会诱发额外的与排乳相关的动作电位爆发。诱发反应的潜伏期为2.9±0.2秒,诱发爆发的大小与自发爆发相似。当动物不进行哺乳时,该刺激绝不会诱发动作电位爆发。这些发现表明,来自乳腺和阴道的两种传入刺激在产生与排乳相关的催产素细胞动作电位爆发时可以相互作用。

相似文献

1
Vaginal distension induces milk ejection-related burst of oxytocin neurones interacting with suckling stimuli in lactating rats.阴道扩张可诱发泌乳大鼠体内与催产素神经元泌乳喷射相关的爆发,并与哺乳刺激相互作用。
Brain Res. 1987 Feb 24;404(1-2):371-4. doi: 10.1016/0006-8993(87)91397-7.
2
Regulation of the milk ejection reflex in the rat.大鼠乳汁排出反射的调节
J Physiol. 1986 Nov;380:239-56. doi: 10.1113/jphysiol.1986.sp016283.
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Facilitatory effect of antidromic stimulation on milk ejection-related activation of oxytocin neurons during suckling in the rat.
Neurosci Lett. 1985 Aug 16;59(1):21-5. doi: 10.1016/0304-3940(85)90209-5.
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Electrophysiological evidence for facilitatory control of oxytocin neurones by oxytocin during suckling in the rat.大鼠哺乳期间催产素对催产素神经元促进性调控的电生理学证据。
J Physiol. 1984 Jul;352:447-66. doi: 10.1113/jphysiol.1984.sp015302.
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Facilitation of milk ejection-related activation of oxytocin-secreting neurones by osmotic stimulation in the rat.渗透刺激对大鼠催产素分泌神经元与排乳相关激活的促进作用。
Exp Brain Res. 1987;65(2):312-6. doi: 10.1007/BF00236303.
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Analysis of bursting responses of oxytocin neurones in the rat in late pregnancy, lactation and after weaning.大鼠妊娠晚期、哺乳期及断奶后催产素神经元爆发反应的分析。
J Physiol. 1995 Jul 1;486 ( Pt 1)(Pt 1):237-48. doi: 10.1113/jphysiol.1995.sp020806.
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Electrophysiological recordings from oxytocinergic neurones during suckling in the unanaesthetized lactating rat.未麻醉泌乳大鼠哺乳期间催产素能神经元的电生理记录。
J Endocrinol. 1981 Aug;90(2):255-65. doi: 10.1677/joe.0.0900255.
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Permissive effect of centrally administered oxytocin on the excitatory response of oxytocin neurones to ventral tegmental stimulation in the suckled lactating rat.
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Milk ejection bursts of supraoptic oxytocin neurones during bilateral and unilateral suckling in the rat.大鼠双侧和单侧哺乳期间视上核催产素神经元的射乳阵发
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Milk ejection burst-like electrical activity evoked in supraoptic oxytocin neurons in slices from lactating rats.在哺乳期大鼠脑片的视上核催产素神经元中诱发的射乳样爆发式电活动。
J Neurophysiol. 2004 May;91(5):2312-21. doi: 10.1152/jn.00697.2003. Epub 2004 Jan 14.

引用本文的文献

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Chronic vs. acute interactions between supraoptic oxytocin neurons and astrocytes during lactation: role of glial fibrillary acidic protein plasticity.哺乳期视上核催产素神经元与星形胶质细胞之间的慢性与急性相互作用:胶质纤维酸性蛋白可塑性的作用
ScientificWorldJournal. 2009 Nov 18;9:1308-20. doi: 10.1100/tsw.2009.148.
2
Interaction of extracellular signal-regulated protein kinase 1/2 with actin cytoskeleton in supraoptic oxytocin neurons and astrocytes: role in burst firing.视上核催产素神经元和星形胶质细胞中细胞外信号调节蛋白激酶1/2与肌动蛋白细胞骨架的相互作用:在爆发式放电中的作用
J Neurosci. 2007 Dec 12;27(50):13822-34. doi: 10.1523/JNEUROSCI.4119-07.2007.
3
Analysis of bursting responses of oxytocin neurones in the rat in late pregnancy, lactation and after weaning.
大鼠妊娠晚期、哺乳期及断奶后催产素神经元爆发反应的分析。
J Physiol. 1995 Jul 1;486 ( Pt 1)(Pt 1):237-48. doi: 10.1113/jphysiol.1995.sp020806.
4
The influence of tactile stimulation of nipples on the milk ejection reflex in the rat.乳头触觉刺激对大鼠排乳反射的影响。
J Comp Physiol A. 1992 Jun;170(5):645-50. doi: 10.1007/BF00199340.