Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey.
Izmir Biomedicine and Genome Center, Izmir, Turkey; Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, Izmir, Turkey; Department of Medical Biology and Genetics, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
Exp Eye Res. 2022 Aug;221:109138. doi: 10.1016/j.exer.2022.109138. Epub 2022 Jun 5.
Aqueous tears secreted by the lacrimal gland have vital importance in maintaining and protecting the ocular surface health. Serious complications such as corneal ulceration, ocular surface keratinization and permanent vision loss can be seen in aqueous deficiency type dry eye disease that develops as a result of irreversible damage in the lacrimal gland. Current treatment options offer only short-term temporary palliation to reduce pain and inflammation on the ocular surface with no long-term improvement in lacrimal gland function. In recent years, the cellular and molecular properties of the lacrimal gland have been better understood, and studies carried out in the field of regenerative medicine show promise for the principal treatment of serious aqueous deficiency dry eye disease. In partial lacrimal gland damage, in situ regeneration can be achieved by using stem cells in the tissue. In total gland damage, healing can occur as a result of transplantation of organoids developed from induced pluripotent stem cells (iPSC) thanks to the tissue engineering method. Here, it is aimed to review the appropriate cellular resources for regeneration and development of functional artificial lacrimal gland by comparing studies using in situ stem cells and iPSC.
泪液由泪腺分泌，对维持和保护眼表健康具有重要意义。由于泪腺不可逆损伤，可发生水样液缺乏型干眼症，导致角膜溃疡、眼表角化和永久性视力丧失等严重并发症。目前的治疗选择只能提供短期的暂时缓解，以减轻眼表的疼痛和炎症，但不能改善泪腺功能。近年来，人们对泪腺的细胞和分子特性有了更好的了解，再生医学领域的研究为严重水样液缺乏性干眼症的主要治疗提供了希望。在部分泪腺损伤中，可以利用组织中的干细胞实现原位再生。在整个腺体损伤中，由于组织工程方法，通过诱导多能干细胞（iPSC）开发的类器官移植可以实现愈合。在这里，通过比较原位干细胞和 iPSC 的研究，旨在通过比较原位干细胞和 iPSC 的研究，探讨用于功能性人工泪腺再生和发育的合适细胞资源。
