Seress L, Mrzljak L
Brain Res. 1987 Mar 3;405(1):169-74. doi: 10.1016/0006-8993(87)91003-1.
The aim of this study was to analyze the granule cell population of the dentate gyrus both in healthy rhesus monkeys and in humans free of mental and neurological disorders. Brains of neonatal and adult rhesus monkeys as well as brains of fetal, neonatal and adult humans were impregnated with Golgi methods. The results show that a significant population of granule cells have basal dendrites in primates. Some basal dendrites curve up into the molecular layer where they have similar morphology as the apical dendrites. In contrast, other basal dendrites protrude into the hilus and they are shorter, thinner and have only a few side branches. The frequency of granule cells with basal dendrites in the human dentate gyrus is twice as much as that of the rhesus monkey. Most of these human granule cells have their basal dendrites in the hilus. This observation confirms the fact that discrepancies occur in the normal morphology of individual neurons between the rodent and primate hippocampal formations. The results indicate that basal dendrites of granule cells are not pathological as previously suggested.
本研究的目的是分析健康恒河猴和无精神及神经疾病的人类齿状回中的颗粒细胞群体。对新生和成年恒河猴的大脑以及胎儿、新生儿和成年人类的大脑采用高尔基方法进行浸染。结果表明，在灵长类动物中，相当数量的颗粒细胞具有基底树突。一些基底树突向上弯曲进入分子层，在那里它们与顶树突具有相似的形态。相比之下，其他基底树突伸入门区，它们更短、更细且只有少数侧支。人类齿状回中具有基底树突的颗粒细胞频率是恒河猴的两倍。这些人类颗粒细胞中的大多数其基底树突位于门区。这一观察结果证实了啮齿动物和灵长类动物海马结构之间单个神经元的正常形态存在差异这一事实。结果表明，颗粒细胞的基底树突并非如先前所认为的那样是病理性的。
