Sakuma Y, Akaishi T
Brain Res. 1987 Mar 31;407(2):401-4. doi: 10.1016/0006-8993(87)91123-1.
The actions of leumorphin, a recently characterized endogenous opioid peptide, oppose of most opioid peptides in facilitating lordosis reflex, a major component of female sexual behavior in the rat. Maximal lordosis appeared promptly after infusion of 1 nmol leumorphin into the ventromedial hypothalamus of ovariectomized estrogen-primed rats. This facilitation lasted for as long as 5 h, unless interrupted by midbrain infusion of an antiserum to prolactin. The result is a discovery of a novel substance of remarkable strength in facilitating lordosis, an effect presumably mediated by midbrain release of prolactin.
亮啡肽是一种最近被鉴定出的内源性阿片肽，其作用与大多数阿片肽相反，它能促进大鼠雌性性行为的主要组成部分——脊柱前凸反射。向切除卵巢并用雌激素预处理的大鼠腹内侧下丘脑注射1纳摩尔亮啡肽后，脊柱前凸立即达到最大值。这种促进作用持续长达5小时，除非通过向中脑注射催乳素抗血清来中断。结果发现了一种在促进脊柱前凸方面具有显著强度的新物质，这种作用可能是由中脑释放催乳素介导的。
