Leonard C T, Goldberger M E
Brain Res. 1987 Mar;429(1):1-14. doi: 10.1016/0165-3806(87)90133-7.
Postural reflexes and locomotion were studied in order to assess the effects of unilateral sensorimotor cortical ablations in neonatal (1 day old) and adult cats. To document the infant lesion effect and to distinguish recovery from sparing of function, development of motor function was studied in neonatal operates and in normal littermates. Once neonatal operates achieved maturity, their motor performance was compared with that of chronic adult operates. The emergence of motor behavior during development in neonatal operates appeared to follow the same pattern as in normal animals although with a protracted time course and motor behavior did not attain the level of maturity of normal animals. Some deficits were not apparent immediately but evolved with time. Adult operates exhibited recovery of function of some behavior but neonatal operates exhibited greater recovery and sparing. Adult operates, like neonatal operates, were able to mask certain deficits by compensatory mechanisms. Kinematic analysis revealed that neonatal and adult operates often executed movements abnormally. It is hypothesized that somewhat different mechanisms underlie recovery in neonatal and adult operated animals.
为了评估单侧感觉运动皮层切除对新生（1日龄）和成年猫的影响，对姿势反射和运动进行了研究。为了记录婴儿期损伤的影响并区分功能恢复与功能保留，对新生手术动物和正常同窝幼崽的运动功能发育进行了研究。一旦新生手术动物达到成熟，就将它们的运动表现与成年慢性手术动物的运动表现进行比较。新生手术动物在发育过程中运动行为的出现似乎与正常动物遵循相同的模式，尽管时间进程延长，且运动行为未达到正常动物的成熟水平。一些缺陷并非立即显现，而是随时间演变。成年手术动物表现出某些行为功能的恢复，但新生手术动物表现出更大程度的恢复和功能保留。成年手术动物与新生手术动物一样，能够通过代偿机制掩盖某些缺陷。运动学分析表明，新生和成年手术动物经常异常地执行动作。据推测，新生和成年手术动物恢复的潜在机制略有不同。
