School of Medicine, University of Dundee, Dundee, DD1 9SY, UK.
NHS Tayside, Dundee, DD1 9SY, UK.
Subst Abuse Treat Prev Policy. 2022 Jun 8;17(1):45. doi: 10.1186/s13011-022-00475-1.
There has been a paradigm shift in the treatment of Hepatitis C (HCV) from the interferon-era to direct-acting antiviral (DAA) drugs. Cure of HCV for the key risk group, those with a history of injecting drug use, may provide a range of benefits to an individual's quality of life that can be additional to that of a clinical cure. The interferon-era provided evidence that cure of HCV can be a turning point for those who use drugs, supporting a recovery journey. There remains a question if DAAs can provide the same opportunity.
We employed a scoping review methodology to consider the additional non-clinical benefits that HCV cure may provide. We used the theoretical construct of recovery capital to consider how these benefits may support a recovery journey in the DAA-era.
Our search provided 2095 articles, from which 35 were included in the analysis. We developed a thematic synthesis of the non-clinical outcomes identified based on the four over-arching themes of recovery capital: physical, cultural, social and human capital. Our review suggests that identity change is a constituent part of each of the recovery capital domains in relation to HCV treatment.
We identified Social Identity Model Of Recovery (SIMOR) as a mechanism through which DAAs may provide non-clinical outcomes to increase recovery capital domains. Further research is required to develop an understanding of the impact a cure of HCV with DAAs may have on identity, overall health and wellbeing and social inclusion to support recovery journeys.
丙型肝炎（HCV）的治疗已经从干扰素时代转变为直接作用抗病毒（DAA）药物。对于有吸毒史的关键风险群体，治愈 HCV 可能会为个人的生活质量带来一系列益处，除了临床治愈之外还有更多的益处。干扰素时代的研究提供了证据，表明治愈 HCV 可能成为吸毒者的转折点，支持他们的康复之旅。但仍存在一个问题，即 DAA 是否也能提供同样的机会。
我们采用了范围综述方法来考虑 HCV 治愈可能提供的额外非临床益处。我们利用康复资本的理论结构来考虑这些益处如何在 DAA 时代支持康复之旅。
我们的搜索提供了 2095 篇文章，其中 35 篇被纳入分析。我们根据康复资本的四个总体主题：身体、文化、社会和人力资本，对确定的非临床结果进行了主题综合。我们的综述表明，在与 HCV 治疗相关的每个康复资本领域中，身份变化都是其中的一个组成部分。
我们确定了“社会康复模型”（SIMOR）作为 DAA 可能提供非临床结果以增加康复资本领域的机制。需要进一步研究以了解 DAA 治愈 HCV 可能对身份、整体健康和幸福感以及社会包容产生的影响，以支持康复之旅。
