Department of Psychological Medicine, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
Eating Disorder Outpatient Service, South London and Maudsley NHS Foundation Trust, London, UK.
Early Interv Psychiatry. 2023 Feb;17(2):202-211. doi: 10.1111/eip.13317. Epub 2022 Jun 8.
First Episode Rapid Early Intervention for Eating Disorders (FREED) is an early intervention model for young people with recent-onset eating disorders (ED). Promising results from a previous single-centre study and a four-centre study (FREED-Up) have led to the rapid national scaling of FREED to ED services in England (FREED-4-All). Our aim was to evaluate duration of an untreated ED (DUED), wait time target adherence, and clinical outcomes in FREED-4-All and compare these to the (benchmark) findings of the earlier FREED-Up study.
FREED services submit de-identified data to the central FREED team quarterly. The current study covers the period between September 2018 and September 2021. This FREED-4-All dataset includes 2473 patients. These were compared to 278 patients from the FREED-Up study.
DUED was substantially shorter in the FREED-4-All dataset relative to the FREED-Up study (15 vs. 18 months). Adherence to the wait time targets was comparable in both cohorts (~85% of engagement calls attempted in <2 days, ~50%-60% of assessments offered in <14 days, ~40% of treatment offered in <28 days). Patients in the FREED-4-All dataset experienced significant improvements in ED and general psychological symptoms from pre- to post-treatment that were comparable to the FREED-Up study. These findings should be interpreted cautiously as only 6% of FREED-4-All patients had post-treatment data.
Data from the FREED-4-All evaluation suggest that FREED is replicating at scale. However, these data are flawed, uncertain, proximate, and sparse and should therefore be used carefully alongside other evidence and clinical experience to inform decision making.
首次发作快速早期干预进食障碍(FREED)是一种针对近期发病进食障碍(ED)的青年患者的早期干预模式。此前一项单中心研究和四项中心研究(FREED-Up)的结果令人鼓舞,这导致 FREED 在英格兰的 ED 服务中迅速全国推广(FREED-4-All)。我们的目的是评估 FREED-4-All 中未治疗的 ED(DUED)持续时间、等待时间目标的遵守情况和临床结果,并将这些结果与早期 FREED-Up 研究的结果(基准)进行比较。
FREED 服务每季度向中央 FREED 团队提交去识别数据。本研究涵盖了 2018 年 9 月至 2021 年 9 月期间。该 FREED-4-All 数据集包括 2473 名患者。将这些患者与 FREED-Up 研究中的 278 名患者进行比较。
FREED-4-All 数据集的 DUED 明显短于 FREED-Up 研究(15 个月 vs. 18 个月)。两个队列的等待时间目标遵守情况相当(约 85%的接触电话尝试在 2 天内完成,约 50%-60%的评估在 14 天内完成,约 40%的治疗在 28 天内完成)。FREED-4-All 数据集的患者在治疗前后的 ED 和一般心理症状均有显著改善,与 FREED-Up 研究相当。这些发现应谨慎解释,因为只有 6%的 FREED-4-All 患者有治疗后数据。
来自 FREED-4-All 评估的数据表明 FREED 在规模上得到了复制。然而,这些数据是有缺陷的、不确定的、接近的和稀疏的,因此应该谨慎地与其他证据和临床经验一起使用,以帮助做出决策。