一名青少年患者的侵袭性自然杀伤细胞白血病：病例报告及文献综述

Yang Rong, Ai Yuan, Liu Chuan, Lu Xiaoxi

Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.

Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.

Front Pediatr. 2022 May 23;10:829927. doi: 10.3389/fped.2022.829927. eCollection 2022.

Aggressive natural killer cell leukemia (ANKL) is a rare malignant tumor, especially uncommon in children. ANKL has very aggressive clinical course and bad prognosis and is usually caused by Epstein-Barr virus infection. ANKL often has clinical manifestations of hemophagocytic lymphohistiocytosis (HLH) and can be easily treated as HLH, which might complicate this aggressive disease. Here we report an ANKL in adolescent whose clinical presentation was highly aggressive and response to L-asparaginase containing chemotherapy was very bad. Early-onset Flow cytometry of peripheral blood and bone marrow help make the diagnosis.

侵袭性自然杀伤细胞白血病（ANKL）是一种罕见的恶性肿瘤，在儿童中尤为少见。ANKL具有非常侵袭性的临床病程和不良预后，通常由EB病毒感染引起。ANKL常伴有噬血细胞性淋巴组织细胞增生症（HLH）的临床表现，且容易被误诊为HLH进行治疗，这可能会使这种侵袭性疾病复杂化。在此，我们报告一例青少年ANKL患者，其临床表现极具侵袭性，对含左旋门冬酰胺酶的化疗反应很差。外周血和骨髓的早期流式细胞术有助于做出诊断。