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黏液活性药物在囊性纤维化中的应用：意大利专家的共识调查

Use of mucoactive agents in cystic fibrosis: A consensus survey of Italian specialists.

作者信息

Volpi Sonia, Carnovale Vincenzo, Colombo Carla, Raia Valeria, Blasi Francesco, Pappagallo Giovanni

机构信息

Cystic Fibrosis Center Azienda Ospedialiera Universitaria Integrata Verona Italy.

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Cystic Fibrosis Center Milan Italy.

出版信息

Health Sci Rep. 2022 Jun 6;5(4):e604. doi: 10.1002/hsr2.604. eCollection 2022 Jul.

DOI:10.1002/hsr2.604
PMID:35677472
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9169509/
Abstract

BACKGROUND

The goal of mucoactive therapies in cystic fibrosis (CF) is to enhance sputum clearance and to reduce a progressive decline in lung function over the patient's lifetime. We aimed to investigate the level of consensus among specialists from Italian CF Centers on appropriateness of therapeutic use of dornase alfa (rhDNase) for CF patients.

METHOD

A consensus on appropriate prescribing in CF mucoactive agents was appraised by an online Delphi method, based on a panel of 27 pulmonologists, coordinated by a Scientific Committee of six experts in medical care of patients with CF.

RESULTS

Full or very high consensus was reached on several issues related to therapeutic use of dornase alfa for CF patients in clinical practice.

CONCLUSIONS

The consensus reached on a number of topics regarding use of mucoactive agents in patients with CF can help guide clinicians in daily practice based on expert experience and define the most appropriate therapeutic strategy for the individual patient.

摘要

背景

囊性纤维化（CF）黏液活性疗法的目标是提高痰液清除率，并减少患者一生中肺功能的渐进性下降。我们旨在调查意大利CF中心的专家对CF患者使用多纳培南（重组人脱氧核糖核酸酶）治疗的适宜性的共识程度。

方法

基于由6名CF患者医疗护理专家组成的科学委员会协调的27名肺科医生小组，通过在线德尔菲法评估CF黏液活性药物合理处方的共识。

结果

在临床实践中，对于CF患者使用多纳培南治疗的若干问题达成了完全或高度共识。

结论

在CF患者使用黏液活性药物的一些问题上达成的共识，有助于根据专家经验指导临床医生的日常实践，并为个体患者确定最合适的治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe8/9169509/fbd9a284e9af/HSR2-5-e604-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe8/9169509/3fa2b560c2d2/HSR2-5-e604-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe8/9169509/9f2d8ba00bb8/HSR2-5-e604-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe8/9169509/1eb10be5fae0/HSR2-5-e604-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe8/9169509/2be5943b5836/HSR2-5-e604-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe8/9169509/4b883fe02137/HSR2-5-e604-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe8/9169509/fbd9a284e9af/HSR2-5-e604-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe8/9169509/3fa2b560c2d2/HSR2-5-e604-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe8/9169509/9f2d8ba00bb8/HSR2-5-e604-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe8/9169509/1eb10be5fae0/HSR2-5-e604-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe8/9169509/2be5943b5836/HSR2-5-e604-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe8/9169509/4b883fe02137/HSR2-5-e604-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fe8/9169509/fbd9a284e9af/HSR2-5-e604-g005.jpg

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本文引用的文献

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Adherence to long-term therapies in cystic fibrosis: a French cross-sectional study linking prescribing, dispensing, and hospitalization data.囊性纤维化患者长期治疗的依从性：一项将处方、配药和住院数据相联系的法国横断面研究。
Patient Prefer Adherence. 2019 Sep 4;13:1497-1510. doi: 10.2147/PPA.S211769. eCollection 2019.
2
Inhaled hypertonic saline in preschool children with cystic fibrosis (SHIP): a multicentre, randomised, double-blind, placebo-controlled trial.吸入高渗盐水治疗囊性纤维化学龄前儿童（SHIP）：一项多中心、随机、双盲、安慰剂对照试验。
Lancet Respir Med. 2019 Sep;7(9):802-809. doi: 10.1016/S2213-2600(19)30187-0. Epub 2019 Jun 6.
3
Adherence to medication in adults with Cystic Fibrosis: An investigation using objective adherence data and the Theoretical Domains Framework.
成人囊性纤维化患者的药物依从性：使用客观依从性数据和理论领域框架进行的调查。
Br J Health Psychol. 2019 May;24(2):357-380. doi: 10.1111/bjhp.12357. Epub 2019 Mar 1.
4
Timing of dornase alfa inhalation for cystic fibrosis.囊性纤维化患者吸入多黏菌素B雾化液的时机。
Cochrane Database Syst Rev. 2018 Nov 12;11(11):CD007923. doi: 10.1002/14651858.CD007923.pub5.
5
Preventive Inhalation of Hypertonic Saline in Infants with Cystic Fibrosis (PRESIS). A Randomized, Double-Blind, Controlled Study.预防囊性纤维化婴儿吸入高渗盐水（PRESIS）。一项随机、双盲、对照研究。
Am J Respir Crit Care Med. 2019 May 15;199(10):1238-1248. doi: 10.1164/rccm.201807-1203OC.
6
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Cochrane Database Syst Rev. 2018 Sep 6;9(9):CD001127. doi: 10.1002/14651858.CD001127.pub4.
7
ECFS best practice guidelines: the 2018 revision.欧洲过敏与临床免疫学会变应原标准：2018 修订版。
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8
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