Computational Biology and Medical Ecology Lab, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
Kunming College of Life Sciences, University of Chinese Academy of Sciences, Kunming, China.
Helicobacter. 2022 Aug;27(4):e12899. doi: 10.1111/hel.12899. Epub 2022 Jun 9.
About a half of the world's population is infected with Helicobacter pylori (H. pylori), but only 1%-3% of them develop gastric cancer. As a primary risk factor for gastric cancer, the relationship between H. pylori infection and gastric microbiome has been a focus in recent years.
We reanalyze 11 human gastric microbiome datasets with or without H. pylori, covering the healthy control (HC) and four disease stages (chronic gastritis (CG), atrophic gastritis (AG), intestinal metaplasia (IM), and gastric cancer (GC)) of gastric cancer development to quantitatively compare the influences of the H. pylori infection and disease stages on the diversity, heterogeneity, and composition of gastric microbiome. Four medical ecology approaches including (i) diversity analysis with Hill numbers, (ii) heterogeneity analysis with Taylor's power law extensions (TPLE), (iii) diversity scaling analysis with diversity-area relationship (DAR) model, and (iv) shared species analysis were applied to fulfill the data reanalysis.
(i) The influences of H. pylori infection on the species diversity, spatial heterogeneity, and potential diversity of gastric microbiome seem to be more prevalent than the influences of disease stages during gastric cancer development. (ii) The influences of H. pyloriinfection on diversity, heterogeneity, and composition of gastric microbiomes in HC, CG, IM, and GC stages appear more prevalent than those in AG stage.
Our study confirmed the impact of H. pylori infection on human gastric microbiomes: The influences of H. pylori infection on the diversity, heterogeneity, and composition of gastric microbiomes appear to be disease-stage dependent.
全世界约有一半的人口感染了幽门螺杆菌（H. pylori），但只有 1%-3%的人会发展为胃癌。作为胃癌的主要危险因素，H. pylori 感染与胃微生物组之间的关系近年来一直是研究的焦点。
我们重新分析了 11 个人类胃微生物组数据集，其中包括或不包括 H. pylori，涵盖了健康对照组（HC）和胃癌发展的四个疾病阶段（慢性萎缩性胃炎（CG）、萎缩性胃炎（AG）、肠上皮化生（IM）和胃癌（GC）），以定量比较 H. pylori 感染和疾病阶段对胃微生物组多样性、异质性和组成的影响。采用了四种医学生态学方法，包括（i）用 Hill 数进行多样性分析，（ii）用泰勒幂律扩展（TPLE）进行异质性分析，（iii）用多样性-面积关系（DAR）模型进行多样性定标分析，和（iv）共享物种分析，来完成数据再分析。
（i）H. pylori 感染对胃微生物组的物种多样性、空间异质性和潜在多样性的影响似乎比胃癌发展过程中疾病阶段的影响更为普遍。（ii）H. pylori 感染对 HC、CG、IM 和 GC 阶段胃微生物组多样性、异质性和组成的影响比 AG 阶段更为普遍。
我们的研究证实了 H. pylori 感染对人类胃微生物组的影响：H. pylori 感染对胃微生物组多样性、异质性和组成的影响似乎与疾病阶段有关。
