Department of Clinical Laboratory, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325001, China.
Small. 2022 Jul;18(27):e2201889. doi: 10.1002/smll.202201889. Epub 2022 Jun 9.
Microneedle arrays (MNs) have a demonstrated value in transdermal drug delivery systems. Attempts to this technology focus on the generation of functional MNs to achieve intelligent drug delivery. Here, multifunctional inverse opal microneedle (IOMN) arrays with the abilities are reported to load various drugs and monitor drug release. The IOMNs are generated by using poly(ethylene glycol) diacrylate (PEGDA) to replicate hierarchical structure templates that are composed of self-assembled silica colloidal nanoparticles in the inverted cone structure wells. Because of their interconnected porous structures, different actives, or drugs can be loaded into the IOMNs without organic solvents and chemical polymerization. It is demonstrated that when these drugs loaded IOMNs pierce the skin at position of interest and for slow release, the average refractive index of the IOMNs decreases with the release process, resulting in a corresponding blueshift of their characteristic spectrum. Thus, by measuring the wavelength shift value of the IOMNs, the amount of released drugs can be monitored, providing essential guidance for efficient clinical treatment. These features indicate that the IOMNs are valuable smart drug delivery systems in personalized therapy.
微针阵列（MNs）在经皮给药系统中具有明显的价值。该技术的尝试主要集中在生成功能性 MNs 以实现智能药物输送。在这里，报道了具有多种功能的反蛋白石微针（IOMN）阵列，具有负载各种药物和监测药物释放的能力。IOMNs 是通过使用聚乙二醇二丙烯酸酯（PEGDA）复制由自组装二氧化硅胶体纳米粒子在倒锥形结构井中组成的分级结构模板而生成的。由于其相互连接的多孔结构，不同的活性剂或药物可以在没有有机溶剂和化学聚合的情况下被载入 IOMNs 中。结果表明，当这些载药 IOMNs 在感兴趣的位置刺穿皮肤并进行缓慢释放时，IOMNs 的平均折射率随着释放过程而降低，导致其特征光谱相应蓝移。因此，通过测量 IOMNs 的波长移动值，可以监测释放的药物量，为高效的临床治疗提供必要的指导。这些特性表明 IOMNs 是个性化治疗中有价值的智能药物输送系统。
