Division of Cardiology, Hôtel-Dieu de France Hospital, Beirut, 175208, Lebanon.
Faculty of Medicine, Saint Joseph University, Beirut, 175208, Lebanon.
Future Cardiol. 2022 Aug;18(8):635-646. doi: 10.2217/fca-2021-0137. Epub 2022 Jun 9.
This study investigated the association between plasma levels of GDF-15, hs-cTnT and NT-proBNP and the presence of coronary artery disease (CAD) in stable patients referred for elective coronary angiography. The outcome of CAD was defined as an ordinal variable with 3 levels. The association between each biomarker and the outcome was tested using the Winell and Lindbäck method. In unadjusted analysis of 252 patients, GDF-15 and hs-cTnT were associated with the presence and extent of CAD. In multivariate regression analysis including traditional risk factors, this association was no longer significant. NT-proBNP, GDF-15 and hs-cTnT plasma levels do not seem to improve the predictive ability of traditional risk factors for CAD in stable patients referred for coronary angiography.
本研究旨在探讨在因选择性冠状动脉造影而就诊的稳定型患者中，血浆 GDF-15、hs-cTnT 和 NT-proBNP 水平与冠状动脉疾病（CAD）之间的关系。CAD 的结局定义为一个具有 3 个水平的有序变量。使用 Winell 和 Lindbäck 方法检验每个生物标志物与结局之间的关系。在对 252 例患者进行的未调整分析中，GDF-15 和 hs-cTnT 与 CAD 的存在和严重程度相关。在包括传统危险因素的多变量回归分析中，这种相关性不再显著。在因冠状动脉造影而就诊的稳定型患者中，NT-proBNP、GDF-15 和 hs-cTnT 血浆水平似乎并不能提高传统危险因素对 CAD 的预测能力。
