Departments of Pediatrics & Neurosciences, Division of Pediatric Neurology, University of the Philippines - Philippine General Hospital, Manila, Philippines.
CNS Oncol. 2022 Sep 1;11(3):CNS89. doi: 10.2217/cns-2022-0009. Epub 2022 Jun 9.
Determine delayed diagnosis measured by prediagnostic symptomatic interval (PSI) among Filipino pediatric brain tumor patients and identify associated factors. Data was collected retrospectively on Philippine General Hospital pediatric brain tumor patients from 2015 to 2019. PSI was calculated. Associated factors were determined. 196 patients were included. Median PSI was 80.5 days. Longer PSI was significantly associated with older age, supratentorial and low-grade tumors, more physician consults prior to subspecialist referral, longer interval from neuroimaging request to facilitation, and those presenting with seizures (11-month delay), poor school performance (1-year delay), behavioral changes (1.3-year delay) and secondary amenorrhea (3-year delay). Delayed diagnosis among Filipino brain tumor patients is associated with age, tumor characteristics and symptoms that are uncommon in this condition. Awareness of these symptoms through physician education, close monitoring of patients, early subspecialist referral and better neuroimaging access may lead to earlier diagnosis.
确定菲律宾儿科脑瘤患者的诊断延迟情况,以预测诊断间隔(PSI)为指标,并分析相关因素。该研究回顾性收集了 2015 年至 2019 年菲律宾总医院儿科脑瘤患者的数据。计算了 PSI,并确定了相关因素。共纳入 196 名患者,PSI 的中位数为 80.5 天。较长的 PSI 与年龄较大、幕上和低级别肿瘤、在转诊至专家前有更多次的医生咨询、神经影像学请求到促进的时间间隔较长、有癫痫发作(11 个月的延迟)、学习成绩差(1 年的延迟)、行为改变(1.3 年的延迟)和继发性闭经(3 年的延迟)显著相关。菲律宾脑瘤患者的诊断延迟与年龄、肿瘤特征和该疾病中不常见的症状有关。通过医生教育提高对这些症状的认识,密切监测患者,及早转诊至专家并改善神经影像学的获取途径,可能有助于更早地诊断。