Department of Physiology, School of Medicine, Trinity College Dublin, Dublin, Ireland.
Division of Sport and Exercise Sciences, School of Applied Sciences, Abertay University, Dundee, United Kingdom.
J Appl Physiol (1985). 2022 Aug 1;133(2):273-287. doi: 10.1152/japplphysiol.00148.2022. Epub 2022 Jun 9.
We assessed the rates of adjustment in oxygen uptake (V̇o) and muscle deoxygenation [i.e., deoxygenated hemoglobin and myoglobin, (HHb + Mb)] during the on-transition to high-intensity cycling initiated from an elevated baseline (work-to-work, w-to-w) before training and at , , , and of low-volume high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) in type 2 diabetes (T2D). Participants were randomly assigned to MICT ( = 11, 50 min of moderate-intensity cycling), HIIT ( = 8, 10 × 1 min of high-intensity cycling separated by 1 min of light cycling) or nonexercising control ( = 9) groups. Exercising groups trained three times per week. Participants completed two w-to-w transitions at each time point consisting of sequential step increments to moderate- and high-intensity work-rates. [HHb + Mb] kinetics were measured by near-infrared spectroscopy at the vastus lateralis muscle. The pretraining time constant of the primary phase of V̇o (V̇o τ) and the amplitude of the V̇o slow component (V̇o) of the high-intensity w-to-w bout decreased ( < 0.05) by a similar magnitude at of training in both MICT (from 56 ± 9 to 43 ± 6 s, and from 0.17 ± 0.07 to 0.09 ± 0.05 L/min, respectively) and HIIT (from 56 ± 8 to 42 ± 6 s, and from 0.18 ± 0.05 to 0.09 ± 0.08 L/min, respectively) with no further changes thereafter. No changes were reported in controls. The parameter estimates of Δ[HHb + Mb] remained unchanged in all groups. MICT and HIIT elicited comparable improvements in V̇o kinetics without changes in muscle deoxygenation kinetics during high-intensity exercise initiated from an elevated baseline in T2D despite training volume and time commitment being ∼50% lower in the HIIT group. Three weeks of high-intensity interval training and moderate-intensity continuous training decreased the time constant of the primary phase of oxygen uptake (V̇o) and amplitude of the V̇o slow component during a high-intensity exercise initiated from an elevated baseline, a protocol that mimics the abrupt metabolic transitions akin to those in daily life, in type 2 diabetes. These V̇o kinetics improvements were maintained until the end of the 12-wk intervention without changes in muscle deoxygenation kinetics.
我们评估了在 2 型糖尿病患者中，从基线升高（工作对工作，w-to-w）开始进行高强度自行车运动的过渡期间，氧气摄取量（V̇o）和肌肉去氧（即去氧合血红蛋白和肌红蛋白，（HHb + Mb））的调整率，在低容量高强度间歇训练（HIIT）和中等强度连续训练（MICT）之前进行训练，以及在训练后的 、 、 、 。参与者被随机分配到 MICT（n = 11，50 分钟的中等强度自行车运动）、HIIT（n = 8，10×1 分钟的高强度自行车运动，由 1 分钟的轻自行车运动隔开）或不运动对照组（n = 9）。运动组每周训练三次。参与者在每个时间点完成两次 w-to-w 过渡，包括逐步增加到中等和高强度工作率。通过近红外光谱在股外侧肌测量 [HHb + Mb]动力学。高强度 w-to-w 回合中 V̇o 主要阶段的初始时间常数（V̇o τ）和 V̇o 缓慢成分的幅度（V̇o）在训练后的 训练中均降低（<0.05），在 MICT（从 56±9 到 43±6 s，从 0.17±0.07 到 0.09±0.05 L/min，分别）和 HIIT（从 56±8 到 42±6 s，从 0.18±0.05 到 0.09±0.08 L/min，分别），此后没有进一步变化。对照组没有报告任何变化。在所有组中，Δ[HHb + Mb]的参数估计值保持不变。尽管 HIIT 组的训练量和时间承诺约低 50%，但在 2 型糖尿病患者中，从基线升高开始进行高强度运动时，MICT 和 HIIT 可引起 V̇o 动力学的相似改善，而肌肉去氧动力学没有变化。3 周的高强度间歇训练和中等强度连续训练降低了从基线升高开始的高强度运动期间的氧气摄取量（V̇o）主要阶段的时间常数和 V̇o 缓慢成分的幅度，这一方案模拟了日常生活中类似的突然代谢转变，在 2 型糖尿病中。这些 V̇o 动力学的改善一直持续到 12 周干预结束，肌肉去氧动力学没有变化。
