Qu Yi-Lun, Dong Zhe-Yi, Cheng Hai-Mei, Liu Qian, Wang Qian, Yang Hong-Tao, Mao Yong-Hui, Li Ji-Jun, Liu Hong-Fang, Geng Yan-Qiu, Huang Wen, Liu Wen-Hu, Xie Hui-di, Peng Fei, Li Shuang, Jiang Shuang-Shuang, Li Wei-Zhen, Duan Shu-Wei, Feng Zhe, Zhang Wei-Guang, Liu Yu-Ning, Tian Jin-Zhou, Chen Xiang-Mei
Department of Nephrology, First Medical Center of Chinese People's Liberation Army General Hospital, Nephrology Institute of the Chinese People's Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, Beijing, 100853, China.
Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China; Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangdong Traditional Chinese Medicine Key Laboratory for Metabolic Diseases, Guangzhou, 510006, China.
Chin J Integr Med. 2023 Apr;29(4):308-315. doi: 10.1007/s11655-022-3520-0. Epub 2022 Jun 9.
To investigate the factors related to renal impairment in patients with diabetic kidney disease (DKD) from the perspective of integrated Chinese and Western medicine.
Totally 492 patients with DKD in 8 Chinese hospitals from October 2017 to July 2019 were included. According to Kidney Disease Improving Global Outcomes (KDIGO) staging guidelines, patients were divided into a chronic kidney disease (CKD) 1-3 group and a CKD 4-5 group. Clinical data were collected, and logistic regression was used to analyze the factors related to different CKD stages in DKD patients.
Demographically, male was a factor related to increased CKD staging in patients with DKD (OR=3.100, P=0.002). In clinical characteristics, course of diabetes >60 months (OR=3.562, P=0.010), anemia (OR=4.176, P<0.001), hyperuricemia (OR=3.352, P<0.001), massive albuminuria (OR=4.058, P=0.002), atherosclerosis (OR=2.153, P=0.007) and blood deficiency syndrome (OR=1.945, P=0.020) were factors related to increased CKD staging in patients with DKD.
Male, course of diabetes >60 months, anemia, hyperuricemia, massive proteinuria, atherosclerosis, and blood deficiency syndrome might indicate more severe degree of renal function damage in patients with DKD. (Registration No. NCT03865914).
从中西医结合的角度探讨糖尿病肾病（DKD）患者肾功能损害的相关因素。
纳入2017年10月至2019年7月期间8家中国医院的492例DKD患者。根据改善全球肾脏病预后组织（KDIGO）分期指南，将患者分为慢性肾脏病（CKD）1 - 3组和CKD 4 - 5组。收集临床资料，并采用逻辑回归分析DKD患者不同CKD分期的相关因素。
在人口统计学方面，男性是DKD患者CKD分期增加的相关因素（OR = 3.100，P = 0.002）。在临床特征方面，糖尿病病程>60个月（OR = 3.562，P = 0.010）、贫血（OR = 4.176，P<0.001）、高尿酸血症（OR = 3.352，P<0.001）、大量蛋白尿（OR = 4.058，P = 0.002）、动脉粥样硬化（OR = 2.153，P = 0.007）和血虚证（OR = 1.945，P = 0.020）是DKD患者CKD分期增加的相关因素。
男性、糖尿病病程>60个月、贫血、高尿酸血症、大量蛋白尿、动脉粥样硬化和血虚证可能提示DKD患者肾功能损害程度更严重。（注册号：NCT03865914）
