Amsterdam UMC location Vrije Universiteit Amsterdam, Obstetrics and Gynecology, Amsterdam, Netherlands.
Amsterdam Reproduction and Development Research Institute, Pregnancy and Birth, Amsterdam, Netherlands.
PLoS One. 2022 Jun 9;17(6):e0268673. doi: 10.1371/journal.pone.0268673. eCollection 2022.
To evaluate the implementation of low-dose aspirin in pregnancy for the prevention of utero-placental complications among gynecologists in the Netherlands between 2016 and 2021. In this timeframe, a national guideline about aspirin in pregnancy was introduced by the Dutch Society of Obstetrics and Gynecology.
A national online survey among Dutch gynecologists and residents was performed. An online questionnaire was distributed among the members of the Dutch Society of Obstetrics and Gynecology in April 2016 and April 2021. Main outcome measure was the proportion of gynecologists indicating prescription of aspirin in pregnancy for high and moderate risk indications.
In 2016, 133 respondents completed the survey, and in 2021 231. For all indications mentioned in the guideline there was an increase in prescribing aspirin in 2021 in comparison to 2016. More specifically, the percentage of gynecologists prescribing aspirin for a history of preeclampsia before 34 weeks, between 34 and 37 weeks and at term increased from respectively 94% to 100%, 39% to 98%, and 15% to 97%. Consultant obstetricians and respondents working in an university hospital did not more often indicate the prescription of aspirin for tertiary care indications in 2021. Future use of a prediction model was suggested in the narrative comments.
Implementation of aspirin in pregnancy among Dutch gynecologists substantially improved after a five year timeframe in which the national guideline on aspirin during pregnancy was introduced and trials confirming the effect of aspirin were published.
评估 2016 年至 2021 年荷兰妇科医生在低剂量阿司匹林预防子宫胎盘并发症方面的实施情况。在此期间，荷兰妇产科协会发布了一份关于妊娠期间阿司匹林使用的国家指南。
对荷兰妇科医生和住院医师进行了一项全国性在线调查。2016 年 4 月和 2021 年 4 月，向荷兰妇产科协会的成员分发了在线问卷。主要观察指标为指示妊娠期间使用阿司匹林的妇科医生比例，包括高风险和中风险指征。
2016 年有 133 名受访者完成了调查，2021 年有 231 名受访者完成了调查。与 2016 年相比，2021 年所有指南中提到的指征中，开具阿司匹林的比例均有所增加。具体而言，对于子痫前期史的患者，在 34 周前、34-37 周和足月时开具阿司匹林的妇科医生比例从 94%增加到 100%、39%增加到 98%和 15%增加到 97%。2021 年，顾问产科医生和在大学医院工作的受访者并没有更多地表示会根据三级护理指征开具阿司匹林。在叙述性评论中，建议未来使用预测模型。
在五年的时间里，随着国家关于妊娠期间使用阿司匹林的指南的发布以及确认阿司匹林疗效的试验的发表，荷兰妇科医生在妊娠期间使用阿司匹林的情况有了显著改善。
