2-苄基丙二酸二甲酯。
imethyl 2-Benzylmalonate.
机构信息
Advanced Research Institute and Department of Chemistry, Taizhou University, Jiaojiang, Zhejiang 318000, P. R. China.
Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China.
出版信息
J Org Chem. 2022 Jul 1;87(13):8697-8708. doi: 10.1021/acs.joc.2c00939. Epub 2022 Jun 9.
An electrochemical dearomatizing spirocyclization of alkynes with dimethyl 2-benzylmalonates for the preparation of spiro[4.5]deca-trienones has been developed. This approach adopts ferrocene (CpFe) as an electrocatalyst to produce carbon-centered radical intermediates from C-H-based malonates, which obviates the forthputting of noble-metal reagents, sacrificial chemical oxidants and 2-bromomalonates. A wide variety of spiro compounds are efficiently prepared with satisfactory results under mild conditions.
一种电化学去芳构化的炔烃与二甲基 2-苄基丙二酸酯的螺环化反应，用于制备螺[4.5]癸-10-三烯酮，已经被开发出来。该方法采用二茂铁（CpFe）作为电催化剂，从基于 C-H 的丙二酸酯中产生碳中心自由基中间体，从而避免了贵金属试剂、牺牲化学氧化剂和 2-溴丙二酸酯的使用。在温和条件下，通过该方法可以有效地制备各种螺环化合物，并且得到了令人满意的结果。
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