Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.
Department of Elderly Health Management, Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong, China.
Ann Epidemiol. 2022 Oct;74:1-7. doi: 10.1016/j.annepidem.2022.05.011. Epub 2022 Jun 6.
To investigate the association of long-term exposure to ambient air pollution with serum liver enzymes in older adults.
In this longitudinal study, we investigated 318,911 adults aged 65 years or older and assessed their long-term residential exposure to particulate matter with an aerodynamic diameter ≤2.5 µm (PM), particulate matter with an aerodynamic diameter ≤10 µm (PM), sulfur dioxide (SO), nitrogen dioxide (NO), carbon monoxide (CO), and ozone (O). Linear mixed models and generalized linear mixed models were implemented for exposure-response analyses.
Each interquartile range (IQR) increase of PM, PM, SO, NO, CO, and O exposures was significantly associated with a 4.6%, 4.6%, 5.6%, 4.6%, 6.2%, and 3.6% increase in alanine aminotransferase (ALT), and a 4.6%, 5.2%, 3.6%, 3.3%, 6.1%, and 4.0% increase in aspartate aminotransferase (AST), respectively. Each IQR increase of PM, PM, SO, NO, CO, and O exposures was significantly associated with a 23%, 24%, 28%, 17%, 31%, and 19% increase in odds of elevated ALT (>40 U/L), and a 32%, 39%, 40%, 32%, 57%, and 25% increase in odds of elevated AST (>40 U/L), respectively.
Long-term exposure to ambient air pollution was significantly associated with increased serum liver enzyme levels in older adults, suggesting that air pollution exposures may induce hepatocellular injury.
研究长期暴露于环境空气污染与老年人血清肝酶之间的关系。
在这项纵向研究中，我们调查了 318911 名年龄在 65 岁或以上的成年人，并评估了他们长期居住环境中细颗粒物（PM2.5）、细颗粒物（PM10）、二氧化硫（SO）、二氧化氮（NO）、一氧化碳（CO）和臭氧（O3）的暴露情况。采用线性混合模型和广义线性混合模型进行暴露-反应分析。
每增加一个四分位间距（IQR）的 PM2.5、PM10、SO、NO、CO 和 O3 暴露，丙氨酸氨基转移酶（ALT）分别显著增加 4.6%、4.6%、5.6%、4.6%、6.2%和 3.6%，天冬氨酸氨基转移酶（AST）分别显著增加 4.6%、5.2%、3.6%、3.3%、6.1%和 4.0%。每增加一个 IQR 的 PM2.5、PM10、SO、NO、CO 和 O3 暴露，ALT（>40 U/L）升高的几率分别显著增加 23%、24%、28%、17%、31%和 19%，AST（>40 U/L）升高的几率分别显著增加 32%、39%、40%、32%、57%和 25%。
长期暴露于环境空气污染与老年人血清肝酶水平升高显著相关，提示空气污染暴露可能导致肝细胞损伤。
