采用新型 PF4 依赖性 P-选择素表达检测方法诊断肝移植后肝素诱导的血小板减少症。
Using novel PF4-dependent P-selectin expression assay to diagnose heparin-induced thrombocytopaenia postliver transplantation.
机构信息
Pharmacy, Froedtert Hospital, Milwaukee, Wisconsin, USA
Pharmacy, Froedtert Hospital, Milwaukee, Wisconsin, USA.
出版信息
BMJ Case Rep. 2022 Jun 9;15(6):e248269. doi: 10.1136/bcr-2021-248269.
Abstract
Heparin-induced thrombocytopaenia (HIT) is a well-known adverse event associated with the use of heparin products. HIT may be difficult to diagnose in patients following liver transplantation as patients routinely require massive transfusion support and immunosuppression. As an alternative or adjunctive to the serotonin release assay, the PF4-dependent P-selectin expression assay (PEA) may be a useful diagnostic test in the determination of HIT in this patient population. In this case, we describe a 63-year-old man who had an orthotopic liver transplant that was complicated by HIT that was diagnosed using the PEA.
摘要
肝素诱导的血小板减少症（HIT）是一种与肝素产品使用相关的已知不良反应。肝移植患者由于常规需要大量输血支持和免疫抑制，因此 HIT 可能难以诊断。作为血清素释放试验的替代或辅助手段，PF4 依赖性 P-选择素表达试验（PEA）可能是该患者人群中确定 HIT 的有用诊断试验。在此例中，我们描述了一位 63 岁男性，他进行了原位肝移植，术后发生 HIT，该病例通过 PEA 进行诊断。
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