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脊髓损伤患者经超三角区回肠膀胱扩大术加膀胱扩大术的长期临床和尿动力学效果。

Long-term clinical and urodynamic effectiveness of augmentation ileocystoplasty with supra-trigonal cystectomy in individuals with spinal cord injury.

机构信息

Neuro-Uro-Andrology Hospital Universitaire R.Poincare, AP-HP, 104 bvd R. Poincare, 92380, Garches, France.

Department of Sport Medicine and Readaptation, Hôpital Foch, 92150, Suresnes, France.

出版信息

World J Urol. 2022 Aug;40(8):2121-2127. doi: 10.1007/s00345-022-04028-w. Epub 2022 Jun 10.

DOI:10.1007/s00345-022-04028-w
PMID:35680652
Abstract

PURPOSE

This study aimed to determine the long-term effectiveness of augmentation ileocystoplasty (AI) associated with supra-trigonal cystectomy on clinical and urodynamic variables, and the safety of the intervention in individuals with spinal cord injury (SCI).

MATERIALS AND METHODS

Single-center, retrospective study of all patients with SCI who underwent AI with supra-trigonal cystectomy from January 1994, with a follow-up of more than 8 years. The primary outcome was the sustained long-term effectiveness of AI with supra-trigonal cystectomy on clinical and urodynamic variables. The secondary outcome was the long-term safety of this procedure.

RESULTS

We included 77 patients: 57% were female, mean (SD) age was 52.0 (13.0) years, 77% had paraplegia, and median time since onset was 25.0 [19; 30] years. Long-term success rate (evaluated 13 [10; 15] years post AI) was 93.5% for urodynamic parameters and 76.6% for urinary incontinence. Results of the short- and long-term post-AI assessments did not differ for any urodynamic or clinical variables. Bladder lithiasis occurred in 20.5% of cases and ≥ 1 febrile urinary tract infection occurred in 55.8%, mostly within the first 2 years of follow-up. No cases of bladder cancer were diagnosed.

CONCLUSION

AI associated with supra-trigonal cystectomy in patients with SCI is safe and effective in both the short term and long term. Regular urodynamic assessment is not necessary in clinically stable patients with low bladder risk; however, close monitoring is important because of the risk of urological complications.

摘要

目的

本研究旨在确定在脊髓损伤(SCI)患者中,行升结肠膀胱扩大术(AI)联合三角区以上膀胱切除术对临床和尿动力学变量的长期有效性,并评估该干预的安全性。

材料与方法

这是一项单中心、回顾性研究,纳入了 1994 年 1 月以来所有接受 AI 联合三角区以上膀胱切除术的 SCI 患者,随访时间超过 8 年。主要结局是 AI 联合三角区以上膀胱切除术对临床和尿动力学变量的长期持续有效性。次要结局是该手术的长期安全性。

结果

我们共纳入 77 例患者:女性占 57%,平均(标准差)年龄为 52.0(13.0)岁,77%为截瘫,发病后中位时间为 25.0 [19;30]年。尿动力学参数的长期成功率(AI 后 13 [10;15]年评估)为 93.5%,尿失禁的长期成功率为 76.6%。AI 后的短期和长期评估结果在任何尿动力学或临床变量方面均无差异。20.5%的病例发生膀胱结石,55.8%的病例发生≥1 次发热性尿路感染,大多数发生在随访的前 2 年内。未诊断出膀胱癌病例。

结论

在 SCI 患者中,AI 联合三角区以上膀胱切除术既安全又有效,无论是短期还是长期。对于低膀胱风险且临床稳定的患者,不需要常规进行尿动力学评估;但是,由于存在泌尿系统并发症的风险,密切监测非常重要。

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本文引用的文献

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Long-term results of augmentation ileocystoplasty in spinal cord injury patients.脊髓损伤患者回肠膀胱扩大术的长期疗效
Cent European J Urol. 2021;74(2):178-184. doi: 10.5173/ceju.2021.0333.R1. Epub 2021 Mar 26.
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Patient Reported Bladder Related Symptoms and Quality of Life after Spinal Cord Injury with Different Bladder Management Strategies.脊髓损伤后不同膀胱管理策略对患者膀胱相关症状和生活质量的影响。
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Botulinum Toxin Type A Injection After Failure of Augmentation Enterocystoplasty Performed for Neurogenic Detrusor Overactivity: Preliminary Results of a Salvage Strategy. The ENTEROTOX Study.
A型肉毒毒素注射治疗神经原性逼尿肌过度活动所致增强型回肠膀胱术后失败:挽救策略的初步结果。ENTEROTOX 研究。
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Long-Term Discontinuation of Botulinum Toxin A Intradetrusor Injections for Neurogenic Detrusor Overactivity: A Multicenter Study.长期中断肉毒毒素 A 膀胱内注射治疗神经源性逼尿肌过度活动症:一项多中心研究。
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Long-term functional outcomes of augmentation cystoplasty in adult spina bifida patients: A single-center experience in a multidisciplinary team.成人脊髓脊膜膨出患者膀胱扩大术的长期功能结果:多学科团队中单中心的经验。
Neurourol Urodyn. 2019 Jan;38(1):330-337. doi: 10.1002/nau.23857. Epub 2018 Oct 23.
6
Surgical management of the neurogenic bladder after spinal cord injury.脊髓损伤后神经原性膀胱的外科治疗。
World J Urol. 2018 Oct;36(10):1569-1576. doi: 10.1007/s00345-018-2294-7. Epub 2018 Apr 21.
7
An International Continence Society (ICS) report on the terminology for adult neurogenic lower urinary tract dysfunction (ANLUTD).国际尿控协会(ICS)关于成人神经性下尿路功能障碍(ANLUTD)术语的报告。
Neurourol Urodyn. 2018 Mar;37(3):1152-1161. doi: 10.1002/nau.23397. Epub 2017 Nov 17.
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Phys Med Rehabil Clin N Am. 2017 Nov;28(4):821-828. doi: 10.1016/j.pmr.2017.06.013.
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Urodynamics in patients with spinal cord injury: A clinical review and best practice paper by a working group of The International Continence Society Urodynamics Committee.脊髓损伤患者的尿动力学:国际尿控协会尿动力学委员会工作组的临床综述和最佳实践论文。
Neurourol Urodyn. 2018 Feb;37(2):581-591. doi: 10.1002/nau.23369. Epub 2017 Aug 1.
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