Neuro-Uro-Andrology Hospital Universitaire R.Poincare, AP-HP, 104 bvd R. Poincare, 92380, Garches, France.
Department of Sport Medicine and Readaptation, Hôpital Foch, 92150, Suresnes, France.
World J Urol. 2022 Aug;40(8):2121-2127. doi: 10.1007/s00345-022-04028-w. Epub 2022 Jun 10.
This study aimed to determine the long-term effectiveness of augmentation ileocystoplasty (AI) associated with supra-trigonal cystectomy on clinical and urodynamic variables, and the safety of the intervention in individuals with spinal cord injury (SCI).
Single-center, retrospective study of all patients with SCI who underwent AI with supra-trigonal cystectomy from January 1994, with a follow-up of more than 8 years. The primary outcome was the sustained long-term effectiveness of AI with supra-trigonal cystectomy on clinical and urodynamic variables. The secondary outcome was the long-term safety of this procedure.
We included 77 patients: 57% were female, mean (SD) age was 52.0 (13.0) years, 77% had paraplegia, and median time since onset was 25.0 [19; 30] years. Long-term success rate (evaluated 13 [10; 15] years post AI) was 93.5% for urodynamic parameters and 76.6% for urinary incontinence. Results of the short- and long-term post-AI assessments did not differ for any urodynamic or clinical variables. Bladder lithiasis occurred in 20.5% of cases and ≥ 1 febrile urinary tract infection occurred in 55.8%, mostly within the first 2 years of follow-up. No cases of bladder cancer were diagnosed.
AI associated with supra-trigonal cystectomy in patients with SCI is safe and effective in both the short term and long term. Regular urodynamic assessment is not necessary in clinically stable patients with low bladder risk; however, close monitoring is important because of the risk of urological complications.
本研究旨在确定在脊髓损伤(SCI)患者中,行升结肠膀胱扩大术(AI)联合三角区以上膀胱切除术对临床和尿动力学变量的长期有效性,并评估该干预的安全性。
这是一项单中心、回顾性研究,纳入了 1994 年 1 月以来所有接受 AI 联合三角区以上膀胱切除术的 SCI 患者,随访时间超过 8 年。主要结局是 AI 联合三角区以上膀胱切除术对临床和尿动力学变量的长期持续有效性。次要结局是该手术的长期安全性。
我们共纳入 77 例患者:女性占 57%,平均(标准差)年龄为 52.0(13.0)岁,77%为截瘫,发病后中位时间为 25.0 [19;30]年。尿动力学参数的长期成功率(AI 后 13 [10;15]年评估)为 93.5%,尿失禁的长期成功率为 76.6%。AI 后的短期和长期评估结果在任何尿动力学或临床变量方面均无差异。20.5%的病例发生膀胱结石,55.8%的病例发生≥1 次发热性尿路感染,大多数发生在随访的前 2 年内。未诊断出膀胱癌病例。
在 SCI 患者中,AI 联合三角区以上膀胱切除术既安全又有效,无论是短期还是长期。对于低膀胱风险且临床稳定的患者,不需要常规进行尿动力学评估;但是,由于存在泌尿系统并发症的风险,密切监测非常重要。