Zhao Jie, Jiang Yan, Hao Si-Guo
Department of Hematology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Department of Hematology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China,E-mail:
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2022 Jun;30(3):955-958. doi: 10.19746/j.cnki.issn.1009-2137.2022.03.047.
Mesenchymal stem cells (MSC) have been widely used in tissue regeneration and treatment graft versus host disease (GVHD) and immune diseases due to their self-renewal, multi-differentiation and immunoregulatory potential. However, more and more scholars begin to put weight on the MSC -derived extracellular vesicles (MSC-EV) for its regulation of inflammation and immunity. MSC-EV can activate the relevant signal pathways and regulate the function and biological behaviors of cells via acting on target cells and mediating communication between cells. MSC-EV has important potential clinical applications for its powerful immunomodulatory and hematopoietic regulatory functions. It is considered as a potential therapeutic tool to treat autoimmune diseases and GVHD. This paper reviewed the immunomodulatory activity of MSC-EV as well as the research progress of MSC-EV in hematopoietic stem cell transplantation, and discussed its potential clinical applications in the future.
间充质干细胞（MSC）因其自我更新、多向分化和免疫调节潜能，已被广泛应用于组织再生、治疗移植物抗宿主病（GVHD）和免疫疾病。然而，越来越多的学者开始重视MSC来源的细胞外囊泡（MSC-EV），因为其对炎症和免疫具有调节作用。MSC-EV可通过作用于靶细胞并介导细胞间通讯，激活相关信号通路，调节细胞的功能和生物学行为。MSC-EV因其强大的免疫调节和造血调节功能，具有重要的潜在临床应用价值。它被认为是治疗自身免疫性疾病和GVHD的一种潜在治疗工具。本文综述了MSC-EV的免疫调节活性以及MSC-EV在造血干细胞移植中的研究进展，并探讨了其未来潜在的临床应用。
