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聚焦振动对人卫星细胞的影响。

Effects of Focused Vibrations on Human Satellite Cells.

机构信息

Department of Medicine and Ageing Sciences, "G. d'Annunzio" University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.

Department of Neuroscience Imaging and Clinical Sciences, "G. d'Annunzio" University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.

出版信息

Int J Mol Sci. 2022 May 27;23(11):6026. doi: 10.3390/ijms23116026.

DOI:10.3390/ijms23116026
PMID:35682706
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9180844/
Abstract

Skeletal muscle consists of long plurinucleate and contractile structures, able to regenerate and repair tissue damage by their resident stem cells: satellite cells (SCs). Reduced skeletal muscle regeneration and progressive atrophy are typical features of sarcopenia, which has important health care implications for humans. Sarcopenia treatment is usually based on physical exercise and nutritional plans, possibly associated with rehabilitation programs, such as vibratory stimulation. Vibrations stimulate muscles and can increase postural stability, balance, and walking in aged and sarcopenic patients. However, the possible direct effect of vibration on SCs is still unclear. Here, we show the effects of focused vibrations administered at increasing time intervals on SCs, isolated from young and aged subjects and cultured in vitro. After stimulations, we found in both young and aged subjects a reduced percentage of apoptotic cells, increased cell size and percentage of aligned cells, mitotic events, and activated cells. We also found an increased number of cells only in young samples. Our results highlight for the first time the presence of direct effects of mechanical vibrations on human SCs. These effects seem to be age-dependent, consisting of a proliferative response of cells derived from young subjects vs. a differentiative response of cells from aged subjects.

摘要

骨骼肌由长多聚核和收缩结构组成，能够通过其驻留的干细胞：卫星细胞（SCs）来再生和修复组织损伤。骨骼肌再生减少和进行性萎缩是肌肉减少症的典型特征，这对人类的健康护理具有重要意义。肌肉减少症的治疗通常基于体育锻炼和营养计划，可能与康复计划（如振动刺激）相关。振动刺激肌肉，可以增加老年人和肌肉减少症患者的姿势稳定性、平衡和行走能力。然而，振动对SCs 的可能直接影响尚不清楚。在这里，我们展示了从年轻和年老的个体中分离出来并在体外培养的SCs 接受不同时间间隔的聚焦振动刺激后的影响。刺激后，我们在年轻和年老的个体中均发现凋亡细胞的百分比降低、细胞尺寸和排列细胞的百分比增加、有丝分裂事件和激活细胞。我们还发现仅在年轻样本中存在更多的细胞。我们的研究结果首次强调了机械振动对人SCs 的直接作用。这些影响似乎与年龄有关，表现为来自年轻个体的细胞的增殖反应与来自年老个体的细胞的分化反应。

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